Best Amino Acids for the Ketogenic Diet: Which Ketogenic Amino Acids Should You Be Eating?

The value of a ketogenic diet? To burn fat rather than just lose weight on the scale. The core question: in what foods can the six essential ketogenic amino acids be found?

The value of a ketogenic diet? To burn fat rather than just lose weight on the scale. Beginners at dieting often attempt to lose weight with short-term crash diets, which put the body in starvation mode and cause it to stockpile more fat as soon as possible (an evolutionary protection against times of famine). Conversely, the ketogenic diet puts the body into more of a sustainability mode, a stable way to reduce and optimize calorie intake, while focusing on foods that provide the essential amino acids for the ketogenic conversion of fat into energy.

So which ketogenic amino acids should you be eating, and where can you find them?

Amino Acids: the Fat Burning, the Sugar Forming, and the Switch Hitters

The building blocks of protein, amino acids can be categorized as exclusively ketogenic, exclusively glucogenic, or like Dr. Jekyll and Mr. Hyde: radically both. This is based on the end products produced during amino acid metabolism.

Essential amino acids for the ketogenic diet.

As you can see, the predominant category is the glucogenic group, with 13 amino acids. The carbon skeletons that result from the breakdown of glucogenic amino acids can be used via gluconeogenesis to synthesize glucose, simple sugar and an important energy source found in many carbohydrates. These are not the amino acids that will derive energy from your body’s pre-existing fat stores.

The second largest category contains five amino acids, the switch hitters that when catabolized can yield both glucogenic and ketogenic products.

Exclusively ketogenic amino acids are just that: exclusive. Lysine and leucine are the only two amino acids that produce Acetyl CoA or Acetoacetyl CoA without any glucogenic byproducts.

Acetyl CoA (the precursor of ketone bodies) and Acetoacetyl CoA are the first steps of the Krebs Cycle of energy production, which combines glycolysis and pyruvate oxidation with the citric acid cycle (which itself includes α-ketoglutarate, succinyl CoA, fumarate, and oxaloacetate—all byproducts of glucogenic amino acids). To access citrate synthase, the catalyst of this cycle, without glucose or carbohydrates is the value of ketogenic amino acids: it’s like buying the product you need without bringing home any unnecessary or harmful packaging around it.

Acid Eater: the Amino Acids Essential to a Ketogenic Diet

Classes of amino acids can be further categorized as essential vs. nonessential, essential being the ones you must eat to obtain, and nonessential being those that naturally occur in the body, and are not reliant on the food you eat.

Nonessential amino acids:

  • Asparagine
  • Alanine
  • Glutamic acid
  • Aspartic acid

Essential amino acids:

  • Histidine
  • Valine
  • Methionine
  • Isoleucine
  • Phenylalanine
  • Threonine
  • Tryptophan
  • Leucine
  • Lysine

You may have noticed those last two are the exclusively ketogenic amino acids, meaning they only come from sources outside the body. Likewise, four out of five of the switch hitter or versatile amino acids are on this essential list as well, excluding only tyrosine, a conditional essential, as it’s derived from phenylalanine (which is itself essential). Regardless of that particular debate, the core question remains: in what foods can the six essential ketogenic amino acids be found?

The Key Ingredients to Ketogenesis

Intro 101 of the keto diet is to go deeper when dieting, to the cellular level of biological sciences. This is more advanced than the grocery aisle surface choices people often make between low-carb and no-sugar-added options. It’s important to remember that the colorful labeling on the front of food packages can often be subjective. It’s better to know how to read the nutrition label with a keen (keto) eye.

Better yet, know what basic foods have the ketogenic keys to turn fatty acids into ketone bodies. These ketone bodies will then provide energy from your fat stores, without adding carbohydrates, and without impacting insulin or blood sugar levels. Here are where the six essential ketogenic amino acids reside.

1. Isoleucine

Along with leucine and valine (glucogenic), isoleucine is an isomer (isolated form) of leucine that is one of the three branched-chain amino acids (BCAAs), all of which help to promote post-exercise muscle recovery. Involved in hemoglobin production, isoleucine can be found in:

  • Protein sources like meat, fish, and eggs
  • Dairy, particularly cottage cheese
  • Seeds, grains, nuts, and beans including almonds, brown rice, cashews, lentils, and chia seeds

2. Phenylalanine

The source of tyrosine and one of the aromatic amino acids, phenylalanine is used in the biosynthesis of norepinephrine, dopamine, and thyroid hormones (huge players when it comes to mental health). Possibly effective in treating mood disorders, phenylalanine is contained in:

  • Olives, figs, raisins, avocados, pumpkins, and most berries
  • Meat, chicken, fish, and eggs
  • Rice, beans, quinoa, and seeds
  • Spirulina, seaweed, and leafy greens

3. Threonine

An essential nutrient in the diet of vertebrates, threonine supports the central nervous system, along with the heart, liver, and immune system. A key component in the production of collagen, elastin, and muscle tissue, threonine can be gained from:

  • Beans, nuts, lentils, and quinoa
  • Lean beef, lamb, pork, and chicken/turkey
  • Seafood including shellfish, particularly salmon, whelks, cuttlefish, octopus
  • Seeds, including chia and hemp seeds
  • Raisins, figs, avocados, and pumpkin
  • Spirulina, watercress

4. Tryptophan

Needed for nitrogen balance, tryptophan is also used to produce melatonin (for regulating sleep and wakefulness), niacin, and serotonin, the neurotransmitter known as the “happy” chemical. Tryptophan can be found in:

  • Turkey (rather famously), as well as red meat, rabbit and goat meat, eggs, and fish
  • Milk and cheese, particularly reduced fat mozzarella
  • Pumpkin and squash seeds, along with chia, sesame, and sunflower seeds
  • Almonds, peanuts, bananas, and chocolate (ideal ingredients for a sundae)
  • Spirulina

5. Leucine

Another of the BCAAs, and one of the two exclusively ketogenic amino acids, leucine builds muscle by stimulating protein synthesis. It can be sourced from:

  • Nuts, peas, beans, seeds, and pumpkins
  • Chicken, beef, and pork
  • Seafood including tuna
  • Soybeans, whey protein, and plant proteins
  • Cheese, particularly Parmesan

6. Lysine

Necessary in the formation of collagen, connective tissue, and muscle growth and repair in the body, lysine can be found in:

  • Protein sources like meat, poultry, seafood, and eggs
  • Beans, peas, almonds, cashews, and chia seeds
  • Spirulina, parsley
  • Cheese and yogurt
  • Whey protein

The Ketogenic Conclusion

You may have noticed some foods dominating the field; when it comes to essential amino acids for a ketogenic diet, where you find a good source of protein, you often find the ketogenic advantage. Donald K. Layman, Ph.D. along with Nancy R. Rodriguez, Ph.D. penned a paper for Nutrition Today titled “Egg Protein as a Source of Power, Strength, and Energy,” but in it pointed out that egg is not the only food that packs that much value. With so many high-yield proteins, any dietary practice—be it vegetarian, vegan, kosher, or allergy-restrictive—can still gain you the essential amino acids for perfecting your ketogenic journey if you’re diligent about ensuring your protein macros.

Your body is not so much a temple as a laboratory, a series of chemical reactions. Providing your body with the right ketogenic amino acids (instead of an overabundance of glucose precursors) sets you up for the ideal fat-burning catabolic pathways. This leads to healthy protein turnover for muscle growth, weight loss, and the energy to propel you forward.

Taking an essential amino acid supplement (which includes the ketogenic amino acids lysine and leucine) can help protect against any protein insufficiencies you may encounter while following dietary restrictions, such as the high-fat, moderate-protein requirements of the keto diet.

What Is the Keto Diet—and Can Amino Acids and Other Supplements Really Improve Results?

Consistently following a ketogenic diet, or keto diet, is an effective way to lose weight and keep it off. Taking amino acids along with following a keto diet can expedite the metabolic processes responsible for ketogenic weight loss.

People diet for different reasons, such as preventing or treating infection, managing diabetes, gaining muscle mass, or maintaining a healthy weight. Weight loss is the most popular reason for dieting, but weight loss can be quite difficult to achieve depending on the type of diet you follow. If you’re interested in how the foods you eat can impact your weight and well-being, chances are, you’ve encountered the phrase “keto diet,” but you may still be wondering: “What is the keto diet?”

The ketogenic diet, often shortened to the keto diet, is an extremely low-carbohydrate diet approach (even sticter than the infamous Atkins diet) that proponents state can train your body to burn fat more efficiently. Many individuals have shared their experiences using the keto diet to lose weight, improve their overall health, and enhance physical and mental performance, leading to increased interest in the diet. Some of the benefits of the keto diet have been validated by scientific studies and a growing number of medical professionals recommend it as a means of addressing lifestyle-related chronic conditions.

As more and more people adopt a keto diet, often with the goal of losing weight and keeping it off, some have begun exploring whether certain supplements can improve their results. It appears that amino acids show particular promise as a means of enhancing metabolic processes responsible for ketogenic weight loss.

In this article, we’ll provide an introduction to the keto diet, cover some of the most common benefits associated with the keto diet, and then share the best keto diet supplements to take and how those supplements can help accelerate your keto diet results.

What Is the Keto Diet?

The ketogenic diet was developed in the 1920s as a treatment for epilepsy. Traditionally, it was used to treat children, but in recent years, it has been used to treat adults with epilepsy that does not respond to other interventions. And, of course, its use has expanded far beyond that initial medical context.

After the fat-free diet craze went bust, researchers turned their attention to carbohydrates. Ironically, diets that discourage fatty foods often encourage the consumption of low-fat, fat-free, or trans-fat options loaded with highly processed ingredients that the body stores as fat. Low-fat diets tend to place less emphasis on monitoring the intake of carbohydrates, which can greatly jeopardize calorie-burning processes at the cellular level.

Carbohydrates come in many food forms; sugars, complex carbohydrates (starches), and fiber are the three main types. Regularly consuming carbohydrates over time has been linked to higher risk of developing chronic illness, especially cardiovascular disease.

How the Keto Diet Encourages Your Body to Burn More Fat

The foundational principle of the keto diet is rigid carbohydrate restriction. Carbohydrates are the body’s preferred source of fuels; however, your body can also run off of fat. When you keep your carb intake below a certain threshold while adhering to a high-fat diet, your body switches from burning carbs for fuel to burning fat.

The “keto” in ketogenic refers to small fuel molecules called ketones that your body runs off of when it does not have access to significant quantities of glucose (blood sugar) from carbohydrates.

When you eat carbohydrates, your body quickly converts them into glucose via a process called glucogenesis. Excess protein can also be converted to glucose. The glucose produced from carbohydrates and protein can be used to power your body, but any that’s not immediately needed gets stored as fat.

If your body does not have a ready supply of glucose, it switches over to a process called ketogenesis. The liver converts loose fatty acids into ketone bodies that cells use for energy while the body metabolizes fat and burns calories at a high rate. Ketosis, a term that pops up frequently in reference to the keto diet, describes the moment when the body enters the metabolic state in which it’s running off of fat rather than carbohydrates.

The quickest way to enter a state of ketosis is to fast, but that short-term approach has its limitations. Adopting the keto diet allows you to enter and stay in ketosis for a sustained period of time.

Consistently following a comprehensive ketogenic diet, otherwise known as the keto diet, is an effective way to lose weight and keep it off. Taking amino acids along with following a keto diet can expedite the metabolic processes responsible for ketogenic weight loss.

The Basics of the Keto Diet

Entering a state of ketosis does require some number crunching to track nutrient intake, something many other diets involve too. The basic ratios of the keto diet are:

  • 70% to 75% fat
  • 15% to 25% protein
  • 5% carbohydrates

The most crucial aspect of these ratios is carbohydrate intake. Most individuals will need to limit their carb intake to 50 grams or fewer of net carbs per day. Some experience even greater benefits with a daily carb intake below 20 grams.

For the best keto diet results, you will also need to pay attention to how much protein you consume. The bulk of your calories should come from high-fat, moderate-protein foods, since excess quantities of protein can be converted into glucose.

Athletes or individuals who engage in high-intensity activity should monitor their performance when on the keto diet and may require more protein and carbohydrates for peak metabolic function. One to two days of carbohydrate refueling followed by ketogenic dieting the remaining days of the week is a common dietary program for high-endurance performers.

But if you decrease the intensity of your workouts, plan accordingly. A more precision-based model for carbohydrate intake may work best in this instance. Eating easily digestible natural carbohydrates, like honey, 30 minutes prior to a moderate to vigorous workout can offset potential energy deficiencies created by a keto diet meal plan.

7 Health Benefits of the Keto Diet

The time that it takes for you to achieve ketosis depends on how well-adapted your body is to the ketogenic process. The most reliable way to determine whether you have entered a state of ketosis is to use a blood ketone meter, which can gauge ketone levels in your blood.

Optimal ketosis—the point at which you begin to experience the health benefits of the keto diet, such as weight loss—typically begins when blood ketone levels reach between 1.5 mmol/L and 3.0 mmol/L.

For most people, it takes 2 to 3 weeks to reach optimal ketosis. During this time, you may experience symptoms of “keto flu” as your body acclimates to this new metabolic state. Some common side effects people experience during this entry phase include:

  • Mood swings
  • Drowsiness
  • Fatigue
  • Intestinal discomfort

Once you reach ketosis, however, any initial unpleasantness you experienced will clear up and you will begin to reap the health benefits. Here are seven of the most common benefits associated with the keto diet.

1. Sustainable Weight Loss

The keto diet, in essence, turns your body into a fat-burning machine. As you might anticipate, this can have significant benefits when it comes to weight loss. Strong scientific evidence shows that the keto diet dramatically increases the body’s fat-burning capacity while decreasing levels of insulin, a hormone that encourages fat storage.

2. Decreased Hunger

Researchers have also found that the keto diet supports body fat loss while decreasing appetite, making it easier to stick to the meal plans you set up for yourself.

One reason for this is likely that when your body uses fat as its primary fuel source, it has round-the-clock access to weeks or months of stored energy. This eliminates the hunger attacks many experience when their blood sugar spikes and then plummets after a high-carb meal.

3. Balanced Blood Sugar Levels

Adopting a keto diet can help you gain control over your blood sugar levels. For this reason, medical practitioners may recommend the keto diet to patients with type 2 diabetes. The keto diet can not only lead to better management of this condition, but also, as studies have shown, to a reversal of the disease.

Though no randomized, controlled trials have examined whether the keto diet can help prevent or reverse pre-diabetes, its impressive effect as a treatment for full-blown type 2 diabetes along with anecdotal evidence makes a strong case for its likely success.

4. Reduced Risk of Heart Disease

Multiple studies have shown that adopting a low-carb diet, like the keto diet, can positively influence several key risk factors for the development of heart disease, including cholesterol levels. Levels of high-density lipoprotein (HDL) cholesterol and triglycerides consistently drop while low-density lipoprotein (LDL) levels remain fairly stable.

It’s also common for people who switch from, for instance, the standard American diet (aptly abbreviated to SAD), to the keto diet to see decreases in blood pressure numbers.

5. Heightened Cognitive Skills and Mental Clarity

While weight loss and improved physical health rank high among the reasons people try the keto diet, some seek it out for its beneficial impact on cognition.

When the body enters ketosis, your brain activity no longer depends on glucose stores. Instead, it runs off a steady supply of ketones. This can eliminate frustrating issues related to blood sugar swings, such as brain fog and difficulty focusing.

6. Boosted Energy and Endurance

By allowing you to access the vast amounts of energy in your body’s fat stores, the keto diet can keep your vitality high.

While stores of glucose only contain enough energy to fuel you through a few hours of physical exertion, your fat stores could theoretically last for weeks.

7. Better Digestion and Nutrient Absorption

Many find that adopting the keto diet can relieve symptoms of digestive distress associated with IBS and other conditions.

This benefit often sets in rapidly. Within days of following a keto meal plan, individuals report improvements and fewer instances of bloating, gas, and stomach cramps and pain. Consistently following a comprehensive ketogenic diet, otherwise known as the keto diet, is an effective way to lose weight and keep it off. Taking amino acids along with following a keto diet can expedite the metabolic processes responsible for ketogenic weight loss.

It generally takes 3 to 6 months to train your body to reach optimal ketosis at a fast rate.

Once you reach that milestone, you can begin to gradually re-introduce plant-based carbohydrates from fruits and vegetables into your diet. At this stage, it’s particularly important to continue to monitor your protein intake. Protein surges can cause insulin levels to rise in the blood, which can hinder ketosis.

While transitioning into ketosis, it can be beneficial to engage in high-intensity workouts, as doing so will accelerate glycogen depletion. Many find that when they are in a state of ketosis, they feel best when participating in low-impact exercise, such as jogging or speed walking, yoga, swimming, or dancing.

Using Supplements to Improve Your Keto Results

Those who commit to a keto-friendly, low-carb foods centered approach to eating long term often find that adding specific supplements can maximize the benefits of the keto diet while minimizing any less-than-pleasant side effects.

Some supplements help fill in possible deficiencies that can result when personal preferences are overlaid on top of the restrictions built into the keto diet. Others help counteract symptoms of keto flu experienced while the body adapts to a state of ketosis, or enhance athletic performance.

Here are three supplements that can enhance the positive effects linked to the keto diet and offset any unwanted ones.

1. Amino Acids

Amino acids are the building blocks of proteins. Proteins consist of single- or long-chain amino acids and are necessary nutrients for most cell and organ functions. Consuming measured proteins in correct proportion to nutrient fat can facilitate ketosis. Ketogenic amino acids can convert to acetyl-CoA, a precursor of ketone bodies, whereas glucogenic amino acids degrade to glucose.

Lysine and leucine function exclusively as ketogenic amino acids. Isoleucine, phenylalanine, threonine, tryptophan, and tyrosine function both as ketogenic and glucogenic amino acids.

Lysine, leucine, phenylalanine, and tryptophan are all considered essential amino acids—meaning the body cannot synthesize them on its own and they must be acquired through food or supplements. Leucine, for example, can be found in abundant quantities in cheese, soybeans, chicken, nuts, seeds, and seafood.

The branched-chain amino acids (BCAAs)—leucine, isoleucine, and valine—have particular relevance for keto dieters engaged in physical training, as they can help reduce exercise-related muscle damage, muscle soreness, and fatigue during exercise. However, many studies show that the most benefit can be derived from a well-formulated essential amino acid supplement rather than individual amino acid supplements.

For more information on the best amino acids to take to complement a keto diet, check out this article.

2. Beta-Hydroxybutyrate (BHB)

Beta-hydroxybutyrate (BHB) supplements, sometimes referred to as exogenous ketones, may be able to elevate ketone levels, among other desirable benefits.

As we’ve discussed, your body naturally produces ketone bodies through a process called ketogenesis. Some experts believe that exogenous ketones from an external source can increase your blood ketone levels, helping you reach a state of ketosis more quickly.

There’s also some evidence to show that BHB supplements can counteract the fatigue and mood swings that some experience when they start the keto diet. Once you’ve entered ketosis, studies show that these same supplements may help to enhance athletic performance, decrease recovery time between training sessions, and lower appetite levels.

Some general guidelines for a starting dosage for BHB supplements would be to take either 2 BHB oil capsules daily or 1 scoop of BHB oil powder on an empty stomach between meals with 16 ounces of water. You should limit yourself to three such doses per day.

Some individuals experience stomachaches when taking BHB supplements. If you experience digestive upset, try lowering your intake, then gradually increase to the ideal dose.

3. Medium-Chain Triglycerides (MCTs)

Medium-chain triglycerides (MCTs) can be an ideal tool for keto dieting. These fatty acids are used to form ketones in the liver, and supplementing with MCT oil can help you feel more satiated during the ketosis transition.

Keto-friendly coconut oil is a rich natural source of medium-chain triglycerides, although it provides a far less concentrated dose of MCTs than expressly manufactured MCT oils.

MCTs and amino acids work together synergistically. The presence of amino acids in the body supports the essential metabolic process by which the fatty acids are transformed into ketones, and a study published in the journal Comparative Biochemistry and Physiology determined that dietary fat, especially medium-chain fats, helps to regulate amino acid transport.

As researchers study these unique compounds found in healthy dietary fats, they continue to add to the long list of health benefits associated with an increased intake of MCTs, including:

  • Increased fat burning during athletic activity
  • Bolstered growth of good gut flora
  • Lowered cardiovascular risks
  • Protection against neurodegenerative disorders such as Alzheimer’s disease
  • Increased antibacterial, antiviral, and anti-fungal activity

As with BHB supplements, MCT oil supplements, such as these softgels, should be taken with water—in this case, at least an 8-ounce glass. Only one daily dose is needed.

Consistently following a comprehensive ketogenic diet, otherwise known as the keto diet, is an effective way to lose weight and keep it off. Taking amino acids along with following a keto diet can expedite the metabolic processes responsible for ketogenic weight loss.