How to Reduce Inflammation Naturally

Find out the difference between acute and chronic inflammation (one is good, one is bad). Also learn about the natural ways to reduce inflammation and improve your health through lifestyle, exercise, diet, and supplementation. 

Inflammation is one of those necessary evils. Yes, you need an inflammatory response in the body to alert you and your healing resources that something is wrong, and that is healthy inflammation. A twisted ankle, a reaction to stress, a bug or mosquito bite: these are common external examples of inflammation that let you know: you’ve hurt your ankle, you need a vacation, or it’s time to reapply the bug spray.

Unhealthy inflammation is chronic and persistent inflammation that is no longer helping you, only hurting. For instance if your ankle swells up so badly you can’t walk, you have to put ice on it, elevate it, maybe take an anti-inflammatory medication. But how do you reduce inflammation inside your body? You can’t ice your liver! Moreover how do you reduce inflammation naturally, without resorting to taking over-the-counter drugs and risking their side effects? Read on to find ways to reduce overall inflammation through lifestyle, diet, and natural supplements.

What Is Inflammation? Acute vs. Chronic

Acute inflammation is the immune system’s response to injury or foreign substance. It activates inflammation to deal with a specific threat, and then subsides. That inflammatory response includes the increased production of immune cells, cytokines, and white blood cells. The physical signs of acute inflammation are swelling, redness, pain, and heat. This is the healthy function of inflammation.

Chronic inflammation on the other hand is not beneficial to the body, and occurs when your immune system regularly and consistently releases inflammatory chemicals, even when there’s no injury to fix or foreign invader to fight.

To diagnosis chronic inflammation, doctors test for blood markers like interleukin-6 (IL-6), TNF alpha, homocysteine, and C-reactive protein (CRP). This type of inflammation often results from lifestyle factors such as poor diet, obesity, and stress, and is associated with many dangerous health conditions, including:

These are the conditions that can be caused or exacerbated by chronic inflammation, but what causes chronic inflammation itself? There are a few factors.

Habitually consuming high amounts of high-fructose corn syrup, sugar, refined carbs (like white bread), trans fats, and the vegetable oils included in so many processed foods is one contributor. Excessive alcohol intake is another culprit, and so is an inactive or sedentary lifestyle.

Now that you know what chronic inflammation is, where it comes from, and how it works, the final question is: how can you reduce chronic inflammation with natural remedies? Read on for the answers.

How to reduce inflammation naturally.

How to Reduce Inflammation Naturally Through Lifestyle, Diet, and Supplements

Here are several approaches you can take to combat inflammation naturally before resorting to over-the-counter drugs or medications.

Lifestyle Choices and Therapies to Fight Inflammation

Chronic inflammation is also called low-grade or systemic inflammation. There are some ways you can boost your health by managing lifestyle practices and fitness activities. Some practices you may want to adjust are as follows.

  • Avoid smoking
  • Limit alcohol consumption
  • Manage stress naturally (meditation perhaps, or tai chi)
  • Get sufficient sleep
  • Exercise regularly

When it comes to exercise, something as readily available as walking can help improve your health drastically, and when it comes to fitness with meditation, you could look into yoga. Those who practice yoga regularly have lower levels of the inflammatory marker IL-6, up to 41% lower than those who don’t practice yoga.

An Anti-Inflammatory Diet

A diet of anti-inflammatory foods is a huge component to reducing inflammation. As a general rule, you want to eat whole foods rather than processed foods, as they contain more nutrients and antioxidants for your health. Antioxidants help by reducing levels of free radicals in your body, molecules that cause cell damage and oxidative stress.

You’ll also want a healthy dietary balance between carbs, protein, fats, fruits, and veggies to ensure the proper amount of minerals, vitamins, and fiber throughout each day. One diet that’s been scientifically shown to have anti-inflammatory properties is the Mediterranean diet, which entails a high consumption of vegetables, along with olive oil and moderate amounts of lean protein.

Foods to Eat

Healthy eating can help you reduce inflammation in your body. These foods are the answer to how to reduce intestinal inflammation naturally. Reach inside and soothe what ails you!

  • High-fat fruits: Stone fruits like avocados and olives, including their oils
  • Whole grains: Whole grain wheat, barley, quinoa, oats, brown rice, spelt, rye, etc.
  • Vegetables: Leafy green and cruciferous vegetables especially, like kale, broccoli and broccoli greens, Brussels sprouts, cauliflower, and cabbage
  • Fruit: Dark berries like cherries and grapes particularly, either fresh or dried
  • Fatty fish: Salmon, anchovies, sardines, herring, and mackerel for omega-3 fatty acids
  • Nuts: Walnuts, almonds, cashews, Brazil nuts, etc.
  • Spices: Including turmeric, cinnamon, and fenugreek
  • Tea: Green tea especially
  • Red wine: Up to 10 ounces of red wine for men and 5 ounces for women per day
  • Peppers: Chili peppers and bell peppers of any color
  • Chocolate: Dark chocolate specifically, and the higher the cocoa bean percentage, the better

Foods to Avoid

These foods can help cause inflammation and amplify negative inflammatory effects in your body. You’d do well to reduce intake of or avoid entirely.

  • Alcohol: Hard liquors, beers, and ciders
  • Desserts: Candies, cookies, ice creams, and cakes
  • Processed meats: Sausages, hot dogs, and bologna
  • Trans fats: Foods containing partially hydrogenated ingredients like vegetable shortening, coffee creamer, ready-to-use frosting, and stick butter
  • Sugary beverages: Sugar-sweetened fruit juices, sports drinks, etc.
  • Refined carbs: White bread, white pasta, and white rice
  • Processed snacks: Crackers, pretzels, and chips
  • Certain oils and fried foods: Foods prepared with processed vegetable and seed oils like soybean oil, canola oil, corn oil, sunflower oil, etc.

When it comes to how to reduce liver inflammation naturally, what you avoid is just as important as what you put into your body, which is why it’s also recommended to quit smoking and avoid secondhand smoke and to limit your contact with toxic chemicals like aerosol cleaners.

Anti-Inflammatory Natural Supplements

You can help treat inflammation by including certain supplements that reduce inflammation.

Omega-3 Fatty Acids

Supplements like fish oil contain omega-3 fatty acids, and while eating fatty fish can also provide this nutrient, not everyone has the access or means to eat two to three helpings of fish per week.

Though both omega-3 and omega-6 fatty acids are essential to get from our diets, we often have a drastic overabundance of omega-6s and not nearly enough omega-3s to keep the ideal ratio between the two. Likewise, while red meat and dairy products may have anti-inflammatory effects, red meat and dairy are also prohibitive on certain diets and health care regimens (for example, red meat is not recommended for those with heart-health concerns). Supplementing with omega-3 fatty acids or fish oil can help defeat pro-inflammatory factors.

Herbs and Spices

Curcumin, found in the curry spice turmeric, has been shown to fight back against pro-inflammatory cytokines. And ginger also has been found to reduce inflammation even more successfully than NSAIDs (non-steroidal anti-inflammatory drugs) like aspirin, and with fewer side effects. Whether fresh or dried, certain herbs and spices can help reduce inflammation without having any detriment to your overall health.

Flame Off

With these tips, you can help reduce chronic inflammation in your life naturally, and the rewards for taking such precise care of yourself could be great. Those on an anti-inflammatory diet, for example, may find that certain health problems improve, from inflammatory bowel syndrome, to arthritis, to lupus and other autoimmune disorders. Not only that, but a healthier lifestyle leads almost invariably to lowered risk of developing chronic diseases like diabetes, heart disease, obesity, depression, and cancer. You’ll have better cholesterol, triglyceride, and blood sugar levels, plus an improvement in mood and energy. The bottom line is: lowering your levels of inflammation naturally increases your quality of life!

How to Speed up Healing: From Sunburns to Surgery Recovery

The wound healing process, much like our physical activity levels, tends to decline as we age. Here are some scientifically backed tips on the best ways to speed up healing, from minor cuts and scrapes around the home, to post-surgical recovery and muscle tissue rebuilding.

Whether you have a cut, a burn, or are healing from a surgical procedure, there are ways to help speed up healing and close your wounds faster. The wound healing process, much like our physical activity levels, tends to decline as we age. The older we get, the longer our healing time takes, leading in some instances to chronic wounds that never really go away. To speed up wound repair, here are some tips for helping your body along.

Speed up healing: from sunburns to surgery.

At-Home Healing: Small Wounds and Scar Reduction

When it comes to home remedies for wound care, there are a lot of old wives’ tales still around. Some of them make a certain amount of sense when considered scientifically, like waiting 30 minutes to swim after you eat may well help you avoid a minor cramp. However, not all of these folktales are true enough to keep repeating or insisting on. Not everyone will get a minor cramp if they swim after eating, and even if they do, it won’t cause them to drown. And yet still we wait, and tell children to wait, and keep the myth going.

When it comes to how to speed up wound healing, there are a lot of practices that don’t really apply. Some say leaving a wound open to dry in the air and “breathe” helps it heal faster, but that isn’t true if it’s now open to dirt and possible infection. To stop infection, many douse a wound in alcohol or peroxide—talk about pouring salt on a wound!

In truth, leaving a wound to dry out is not ideal, and can even slow healing and increase pain. Wounds need moisture to heal, and moist wound healing speeds up healing and reduces scarring. Here are some other tips on how to foster faster healing and reduce the risk of scarring.

1. Clean and Disinfect

Before touching a wound, wash your hands. When it comes to cleaning the wound, start with clear water and a clean cloth to remove any dirt or particles from the wound. If there are pieces of debris in a wound (your kid took a wipeout on their skateboard and has gravel embedded in the scrape, for example), use a pair of tweezers to remove them. The tweezers should be sterilized with some isopropyl alcohol, but alcohol is not advised directly on the open wound.

Instead, once the wound is clean, apply an antibiotic cream, ointment, or spray to the wound area, and make your call about what kind of bandage applies. If it’s an open wound like a wide scrape, a gauze and a wrap may be called for, but a cut on a finger might need only a bandaid to reduce the risk of infection and speed healing.

Remember not to pick at any scab that forms, because a scab is the body’s natural bandage.

2. Encourage Blood Flow

Nobody can heal you better than your own body, but there are ways to help it along. You’ll notice when you get a scrape or a bruise that the area seems to heat up. That’s because the body has dispatched its in-house medical team via your bloodstream.

To increase blood flow to the skin and surrounding area, you can apply a heating pad or hot water bottle, or place the wound area in some warm water for 15-30 minutes. It’s not a high-tech method but it does help, especially for wounds on your extremities (fingers, toes, arms, and legs) where your blood vessels are smaller, or for anyone with poor circulation, like the elderly.

If adding heat is uncomfortable, massaging the surrounding area is another way to usher blood to the site of injury.

3. Reduce Inflammation

After encouraging healthy blood flow, your wound may experience unhealthy inflammation. A burn that you got from pulling dinner out of the oven might feel like it’s still burning for days after, and you’ll want some kind of anti-inflammatory to help relieve the pain.

Many people think of the gel-like insides of the aloe vera plant for burns, and this is an age-old home remedy that actually works! Aloe vera is a succulent plant originally native to Africa that has a gooey substance in its leaves called mucilaginous juice, and while the plant is 99% water, it does have two chemicals within that improve wound healing.

According to researchers, many of the healing effects of aloe vera are due to the glycoproteins and polysaccharides present in the plant’s pulp. The polysaccharides increase cellular movement, leading to faster tissue regrowth, and the glycoproteins help relieve pain and control the inflammatory response. Together these compounds aid and possibly improve your immune system.

There is even more evidence out of a 2015 study that suggests there are further helpful compounds in aloe vera for cutaneous wounds (like sunburns). For instance, glucomannan stimulates the growth of fibroblasts responsible for collagen, skin cell, and tissue building. Other chemicals found in aloe vera may also help foster blood vessel regrowth, making it a fantastic, natural anti-inflammatory to have on hand for minor wound healing.

4. Get More Protein, Vitamins, and Nutrients

There are certain power foods that contain the nutrients your body needs to rebuild itself, including vitamin C, vitamin D, vitamin E, omega-3 fatty acids, and magnesium. You’ll find these nutrients in dark green leafy vegetables and in orange, yellow, and red fruits and veggies (eat the rainbow!), like bell peppers, tomatoes, oranges, and more.

One of the biggest factors when it comes to tissue and wound healing though? Protein. Omega-3s come from fish along with fish’s protein content, and you can get an assortment of your essential amino acids from various meats and dairy products.

Amino acids are needed for wound healing, so if you’re not a meat-eater, you can increase your protein intake with certain vegetarian and vegan protein foods, or with an amino acid supplement while you heal.

How to Speed up Healing After Surgery

Outside of household and playground injuries, recovery after surgery is a whole different ball game. No matter where it is on the body or how good the chances for a speedy recovery are, surgery still carries a certain amount of risk, and so does surgical recovery. Once you’re sent home from your procedure, you’re going to want to heal as quickly and safely as possible. Here are some tips for how to do so.

1. Follow Your Doctor’s Instructions

While it’s true that no one knows your body quite like you do, doctors don’t give out suggestions willy-nilly. Their medical advice is based on data and research collected from all different kinds of patients over years and years of procedures.

If a doctor tells you to avoid activities for a specific amount of time after a procedure, it’s in your best interest to heed that advice. If you’re told to avoid driving, avoid sexual intercourse, avoid alcohol, or avoid lifting anything over 10 pounds for a couple of weeks, this is for your safety, and so you don’t end up back in their office with a new injury or complication. You may be feeling good enough to return to normal activity, and that’s great, it means your healing is right on course! And yet there may still be healing processes going on beneath your skin that need a little bit more time.

2. Eat the Right Recovery Foods

As true as it was for minor wounds, eating a nutrient-dense diet is even more important after a surgery, because you’re healing much deeper wounds. Although you may have a loss of appetite or digestive discomfort after a surgery, it’s important that you eat a healthy diet by any means necessary (broths, smoothies, amino acid powders), because certain foods are actually going to feed your recovery process.

Again, vitamin C and zinc can help with healing, and can be had from fruit and beans. Iron and vitamin B12 help in forming new blood cells and can be found in fish and eggs. Sports and sugary drinks should be avoided for the time being, as should refined sugar foods.

Protein is more important than ever, as many surgeries by nature involve cutting through tissue and muscle, and the amino acids in protein can help speed post-surgical recovery. Meat, poultry, fish, and eggs are all strong sources of protein, but if a doctor tells you to take a protein supplement, look for a comprehensive amino acid supplement. For recovering after surgery, you may need more protein than a normal diet or your appetite can provide, and supplementing may be a necessity.

3. Follow-up, Ask For Help, and Get Moving Gradually

Surgical recovery may take a while and involve follow-up appointments, physical therapy, and/or at-home assistance. During this time, it’s important to keep all appointments with your health care team, because a diagnostic such as bloodwork could alert your doctor to a problem before it becomes an infection. Likewise, physical therapy could help you correct something like a limp before it becomes a misalignment.

Asking for help from your family or your medical team may not be your usual tendency, but it is necessary and encouraged for the sake of a speedy and successful recovery. If problems are allowed to fester, you could end up back in the hospital or on bedrest, and in danger of new problems altogether, like muscle atrophy.

4. Don’t Smoke

This is a tip that may not apply to all, so if you don’t smoke or have never smoked, skip ahead. However, if you are a smoker or live with one, the effects of cigarette smoking can counteract your wound healing.

Nicotine tightens blood vessels, and the more constricted your blood vessels are, the harder it is for all the other recovery work you’re doing to matter. The nutrients you eat won’t be going to the right places, the muscle you’re building takes longer to thrive, your wounds take longer to heal, and more carcinogens and harmful substances are coming in at the same time. If you’ve ever wanted to quit smoking, after a surgery it’s more important than ever, and can make even more of a positive health impact.

The Need for Speed

Some things can’t be rushed, and a lot of the time your health is the tortoise racing against the hare: slow and steady wins the race. Diet and exercise are long-haul habits that make all the difference. While that’s also true when it comes to a lot of aspects of healing, the more you can do to support your body’s healing mechanisms and get out of their way, the faster the process goes and the lower the chance you’ll have any more problems arising from the initial issue.

Whether it’s a cut, a sunburn, a broken limb, or a surgical operation, anything can go from bad to worse if you’re not careful. Luckily there are resources you can use and advice to be had on how to speed up healing in a successful and sustainable way. Take these tips into consideration, seek medical advice if needed, and know that we wish you a speedy recovery.

Caffeine Withdrawal: Symptoms and Solutions

Learn about the symptoms of caffeine withdrawal, ranging from mild to severe. Also check out some tips on how to wean yourself from caffeine without the discomfort of withdrawal.

If you’ve ever had a coffee or soda habit, you may have experienced caffeine withdrawal symptoms. They’re uncomfortable, sometimes flu-like symptoms that can distract you from your work, disrupt your sleep, and make you irritable around your loved ones. Because coffee and soda are such normal beverages around the home and workplace, it can be easy to forget that caffeine, though mild, is still a drug just like any other. In fact, the American Psychiatric Association included “Caffeine Withdrawal” in a recent edition of the Diagnostic and Statistical Manual of Mental Disorders (the DSM-51), a publication for health care professionals that describes the criteria of mental disorders. Caffeine withdrawal causes real symptoms in the human body, and this article will describe some of those symptoms, and a few different methods you can use to relieve them.

Caffeine withdrawal: symptoms and solutions.

Common Symptoms of Caffeine Withdrawal

Caffeine is a stimulant to the central nervous system, and it is also the world’s most commonly used psychoactive substance. Caffeine affects your neural activity, increasing alertness and reducing fatigue. If you regularly consume caffeine your body begins to rely on it, and when you stop, you can experience withdrawal. Here is a list of some common symptoms of caffeine withdrawal.

1. Headache

One of the most commonly reported symptoms of caffeine withdrawal, headaches are caused because caffeine constricts blood vessels in the brain, slowing the blood flow. One study showed that those who consume fewer than 3 cups of coffee a day can reduce their cerebral blood flow by up to 27%. Once the blood vessels narrow, reducing your caffeine consumption allows the blood flow to increase to the brain again, which can cause painful, sometimes severe headaches as the brain readapts. The headaches will eventually subside, but read to the end of this article to find our suggested solutions for relieving the symptoms of caffeine withdrawal.

2. Difficulty Concentrating

Coffee, tea, and energy drinks with caffeine are often taken to boost concentration, so when you suddenly stop consuming them, that benefit ends. Caffeinated beverages are often used to improve focus before tests, athletic events, or presentations because caffeine causes your adrenal glands to up their production of adrenaline. Caffeine also boosts your excitatory neurotransmitters, norepinephrine and dopamine. Overall, caffeine works by raising your heart rate, your blood pressure, and stimulating your brain. Phasing out caffeine forces your body to suddenly adapt to doing without all those perks.

3. Fatigue

That feeling of tiredness you often use a cup of coffee to counteract? If you quit caffeine, that fatigue may return with a vengeance. Caffeine increases alertness by blocking adenosine receptors, a neurotransmitter that causes drowsiness. When that is removed from your body’s chemistry, the adenosine comes right back, and affects you in a way you may have become unaccustomed to dealing with on your own.

One study of 213 habitual caffeine drinkers showed that abstaining from caffeine for only 16 hours caused feelings of fatigue. Those who consumed caffeine the most had much more severe withdrawal symptoms. Because the energy caffeine provides only lasts up to 4-6 hours, it becomes easy for normal users to get into the habit of drinking multiple cups of coffee or energy drinks each day, just to maintain their desired level of alertness. It also deepens their dependency.

4. Anxiety

Because caffeine is a stimulant that increases your blood pressure, heart rate, and the stress hormones epinephrine and cortisol, just 1 cup of coffee can make some people anxious and jittery. However, suddenly stopping your caffeine consumption can cause this side effect as well, as your body has become physically and mentally dependent on a substance it’s no longer getting. Moreover if you take your caffeine in the form of soda or sweetened coffee you may be feeling the lack of sugar intake as well, which could amp up the restlessness and anxiety you feel and make your caffeine withdrawal even worse.

5. Irritability

Regular coffee drinkers are often cranky or irritable before their morning cup of java. It’s a lack of caffeine that may be the cause of that, because caffeine only lasts in your system for 4-6 hours and it’s worn off after a night’s rest. As coffee drinkers are used to the mood-altering effects of caffeine, the lack of it can bring feelings of irritability. One study of 94 caffeine drinkers who wanted to cut back on their caffeine intake showed that 89% of the participants were unsuccessful, reportedly due to the symptoms of withdrawal, which included anger and irritability.

6. Depressed Mood

Caffeine is well known for perking people up and elevating their mood because it blocks adenosine receptors. Studies have shown that those who consume caffeine regularly have a more positive mood compared to those taking a placebo. It can go so far as to reduce the risk of depression, as seen in one study on over 50,000 women which found that those who drank 4 or more cups of coffee a day had a 20% lower risk of depression. Removing those benefits by ceasing caffeine consumption can cause a depression in mood, a side effect that could be quite dangerous, as depression is a serious condition that could alter someone’s life for the worse.

7. Tremors

Another serious side effect of caffeine withdrawal: tremors. Those with a serious dependency may find their hands shake after they quit caffeine, because caffeine is a stimulant of the central nervous system. Quitting cold turkey could be ill advised for those with anxiety disorders or a long-term caffeine addiction, as these hand tremors could last between 2 and 9 days after stopping caffeine intake. Tremors lasting any longer than that may mean you need to consult a medical professional to make sure there isn’t an underlying cause beyond consuming too much caffeine.

Ways to Reduce Caffeine Withdrawal Symptoms

Here are some tips for treating caffeine withdrawal symptoms.

1. Over-the-Counter Medications

For headaches or difficulty falling asleep, over-the-counter medications like pain relievers and sleep aids can help in the short term, to get you past those first few days of caffeine withdrawal. Ibuprofen (Advil), acetaminophen (Tylenol), and aspirin (Bayer) can help a caffeine withdrawal headache, but be sure to take them as instructed on the label, as some medications can cause stomach bleeding or kidney damage if overused.

2. Reduce Slowly and Stay Hydrated

Reducing your dependence on caffeine slowly is a way to minimize withdrawal symptoms while avoiding over-the-counter drugs. If you are drinking multiple cups of coffee a day, for example, you may want to take a month and reduce your caffeine consumption by 25% each week. That means 4 cups a day on a usual week should go down to 3 cups the next week, and so on until you can experience milder withdrawal symptoms. Switching to decaf or herbal tea after that can help you keep your habits and obey your taste cravings, and staying hydrated reduces instances of headache.

3. Amino Acids for Caffeine Withdrawal

Another option you might try is supplementing with the amino acid L-tyrosine for caffeine withdrawal (also known as tyrosine). Your brain synthesizes dopamine from tyrosine, which is normally gained from either high-protein food sources (cod, eggs, spirulina, beef, poultry, pork, dairy products, avocados, nuts, and seeds), or from another amino acid, phenylalanine.

The brain overproduces dopamine when you consume caffeine, first depleting your stores of tyrosine, then phenylalanine. When you stop caffeine consumption suddenly, your body may be unable to normally produce dopamine for a short time until it replenishes its amino acid stores.

Supplementing with a comprehensive amino acid supplement that includes tyrosine or phenylalanine (which helps restore both of them), could help you quit caffeine cold turkey, but without the cravings and withdrawal symptoms.

The last facet will be to replace the behaviors around caffeine consumption: heading to a coffee shop, having a soda as a midday pick-me-up, or relying on energy drinks when you need to focus. Replacing behavioral habits with new ones, and replacing your physiological dependence with the help of an amino acid supplement, may allow you to skip the backlash of removing daily caffeine from your life (and help keep you from backsliding into a habit you no longer want to participate in).

Remove Caffeine from Your Routine

Caffeine dependence is a very common predicament in the modern world. Most people are able to kick the habit on their own eventually, but relapsing is a common occurrence too. Consider using the tips above to stick to your new caffeine-free resolution, and consult a medical professional if you notice extreme withdrawal symptoms like double vision, confusion, or nausea, especially if they persist for longer than 9 days. Other than that, quitting caffeine is definitely doable, and you know you have the strength to see it through.

Top 10 Foods with Magnesium

Utilized in hundreds of reactions within the body, magnesium is an important mineral for human functioning. Here are the top 10 foods with magnesium, their health benefits, and other nutrients they provide. 

Utilized in hundreds of reactions within the body, magnesium is an important mineral for human functioning. Foods with magnesium are the best way to get the recommended daily intake (RDI) of magnesium, which is 400 milligrams for adults. This article will let you know what magnesium does, what a magnesium deficiency feels like, and which foods high in magnesium will up your magnesium intake to the levels you need to be at optimal health.

Why You Need Magnesium

Magnesium is a co-factor for hundreds of the body’s enzyme reactions. These processes include DNA synthesis, bone health, blood sugar balance, blood pressure regulation, muscle contractions, a functioning nervous system, and energy conversion from proteins, carbohydrates, and fats. Magnesium is also thought to impact sleep quality.

Symptoms of Magnesium Deficiency

Luckily, magnesium deficiency is not common in adults who are otherwise healthy. Our kidneys store magnesium for use in short-term magnesium lows, but during a long-term low intake of magnesium, it is possible to become deficient.

The most notable sign of inadequate magnesium levels is a dip in energy, but because magnesium has a hand in regulating calcium, vitamin D, and hormonal balance, low magnesium levels can lead to eye tics, anxiety, insomnia, muscle cramps, and fatigue. Here is a list of common symptoms of magnesium deficiency.

  • Fatigue
  • Weakness
  • Loss of appetite
  • Nausea
  • Vomiting
  • Abnormal heart rhythms
  • Muscle cramps and contractions
  • Numbness and tingling

When magnesium levels are low, you might start craving stimulants like coffee (a desire meant to boost our energy back up), or chocolate, which if it comes in the form of dark chocolate, would actually help, as dark chocolate is one of the foods with noteworthy magnesium content. Read on for more beneficial foods for magnesium deficiency.

Top 10 List of Foods with Magnesium

If you’re wondering which foods contain magnesium, you’ve arrived at your answer. Below are 10 magnesium-rich foods, and the other proven health benefits they can offer you.

The top 10 foods with magnesium.

1. Dark Chocolate

Not the sweet milk chocolate common around Halloween and Easter, but dark chocolate, which is both delicious and healthy in more ways than one. Dark chocolate is quite rich in magnesium, with 64 milligrams in a 1-ounce serving, or 16% of the recommended daily intake value. Dark chocolate also contains manganese, copper, and iron, plus prebiotic content, valuable for feeding your healthy gut bacteria.

The benefits don’t stop: dark chocolate is also full of antioxidants, nutrients that protect against the damage caused by free radicals in the body. The flavanols in dark chocolate contribute to heart health. These antioxidants help prevent harmful LDL cholesterol from sticking to the linings of your arteries. Make sure the dark chocolate you get is at least 70% cocoa solids. The higher the percentage, the more benefits you’ll gain.

2. Tofu

Well known as a staple of vegan and vegetarian diets thanks to its high protein content, tofu is a soy product, a bean curd made by pressing soybean milk into curd form. A serving of 100 grams of tofu contains 53 milligrams of magnesium, which is 13% of the recommended daily intake. That same serving size will bring you 10 grams of protein, as well as at least 10% of the RDI for manganese, iron, and selenium. Tofu is also among foods with high magnesium and calcium content.

Studies link eating tofu with a reduction of stomach cancer risk factors and improved health of your artery linings. Tofu is a top magnesium contender and one of the best sources for plant-based protein.

3. Avocados

The avocado has had a renaissance in recent years, acknowledged for being the incredibly nutritious superfood that it is. Avocados are stone fruits, tasty sources of healthy fats and magnesium, providing 58 milligrams for every medium avocado, 15% of the recommended daily intake.

It doesn’t stop there, avocados are especially heart healthy because they are high in both magnesium and potassium; not to mention, B vitamins and vitamin K. Avocados have valuable fiber for comfortable digestion, with 13 out of the 17 grams of carbs in the common avocado coming from fiber. Studies have found that eating avocados can improve cholesterol levels, reduce inflammation, and provide increased feelings of satiety after a meal.

4. Whole Grains

Whole grains like whole wheat, brown rice, oats, and barley, plus pseudocereals like quinoa and buckwheat are all sources of dietary magnesium, as well as various other nutrients. A 1-ounce serving of buckwheat for example has 65 milligrams of magnesium, 16% of the recommended daily intake.

Whole grains also tend to be high in B vitamins, manganese, fiber, and selenium, and have been shown to reduce unnecessary inflammation, which can then lend itself to a decreased risk of heart disease. Buckwheat and quinoa are also significantly higher in antioxidants and protein than traditional grain like corn, and they are gluten-free, so a great resource for those with celiac disease or a sensitivity to gluten.

5. Nuts

Nuts particularly high in magnesium include cashews, almonds, and Brazil nuts. A 1-ounce serving of cashews delivers 82 milligrams of magnesium, or 20% of the recommended daily intake. Nuts are also excellent sources of monounsaturated fat and fiber, making them good for regulating cholesterol levels and blood sugar for those with type 2 diabetes. Brazil nuts are high in selenium, providing over 100% of the recommended daily intake with just two nuts, but most nuts are equipped with anti-inflammatory properties and are beneficial for heart health.

6. Seeds

The majority of people in the modern world are not eating enough seeds. Whether it’s flaxseeds, pumpkin seeds, chia seeds, or sunflower seeds, most seeds contain high levels of magnesium. Pumpkin seeds have an especially high amount of magnesium compared to other seeds, with 150 milligrams per 1-ounce serving, a remarkable 37% of the recommended daily intake.

Seeds are also rich in omega-3 fatty acids, monounsaturated fat, and iron, as well as high in dietary fiber. With antioxidants to protect against free radicals, flaxseeds specifically have been shown to reduce cholesterol and have been linked to breast cancer prevention. These tiny powerhouses of nutrients are easy to quickly add to your diet with trail mixes, smoothies, and overnight oat recipes.

7. Legumes

Legumes include chickpeas, kidney beans, lentils, peas, and soybeans. Not only do they contain magnesium (like black beans, which have 120 milligrams of magnesium per cooked cup, or 30% of the recommended daily intake), but legumes also provide a major plant-based food source of protein.

High in iron and potassium, both good for blood and heart health, legumes help decrease the risk of heart disease and improve blood sugar control when eaten regularly. Legumes also contain high amounts of fiber and have a low glycemic index number, making them a beneficial food for diabetics. Another legume resource: natto, a fermented soybean product that can provide you with vitamin K, valuable for bone health.

8. Bananas

Well known as a source of potassium, the banana is a popular fruit worldwide that can help reduce the risk of heart disease, and lower blood pressure. Bananas are also rich in magnesium, with one large banana containing as much as 37 milligrams, 9% of the recommended daily intake.

With vitamin C, manganese, fiber, and vitamin B6, bananas are nutritionally rich and highly convenient to eat: they come in their own protective peel and can easily be included in delicious treats like peanut butter banana smoothies, or made into a dairy-free version of ice cream if you freeze them.

While fully ripe bananas are higher in sugar and carbs than most other fruits, they are natural sugars, much better for your health than refined sugars. On top of that, a large amount of the carbs in unripe bananas are resistant starch, which doesn’t get absorbed and digested and may help lower blood sugar levels by reducing inflammation and promoting gut health.

9. Certain Fatty Fish

Fish have a lean protein content that can’t be beat, plus omega-3 fatty acids in certain oily fish like salmon, halibut, and mackerel provide an extra health boon. These fish are also high in magnesium, with half a fillet of salmon (about 178 grams) containing 53 milligrams of magnesium, or 13% of the recommended daily value. Fish are also rich in B vitamins, selenium, and potassium, and a regular intake of fatty fish has been scientifically linked to a decrease in heart disease and other chronic diseases.

10. Leafy Greens

Green, leafy vegetables are highly healthy, full of magnesium, iron, and large amounts of vitamins A, C, and K. Leafy greens include spinach, kale, Swiss chard, turnip greens, collard greens, and mustard greens. A cup of cooked spinach for example contains 157 milligrams of magnesium, a whopping 39% of the recommended daily intake. Moreover, the plant compounds in these leafy greens have been linked with anti-cancer properties and may help prevent DNA and cell damage.

Magnificent Magnesium

These healthful magnesium foods can help those with high blood pressure, diabetes, and high blood sugar. Before trying a magnesium supplement (which should be done under the guidance of health professionals), use these foods with high magnesium to try and get enough magnesium from your dietary sources first. Dietary supplements are important when needed, but nothing quite beats getting all the nutrients you need from a well-balanced diet, including magnesium.

Top 12 Foods with Zinc

Find out the symptoms and consequences of zinc deficiency, plus the top 12 foods that contain zinc and can provide you with this essential nutrient for your senses, growth, and healing. 

Zinc is a trace mineral found throughout the body that is necessary for our immune system’s function, cell growth and division, wound healing, and our senses of taste and smell. Zinc is needed in over 300 enzyme functions in the body, and yet the body doesn’t store zinc as a reserve. Instead, zinc is used as needed to metabolize nutrients, and so we need to get a regular supply of it via our food or dietary supplement. For men this means 11 milligrams of zinc per day, and for women, it’s 8 milligrams unless they are pregnant or breastfeeding, when the requirement jumps up to 12 milligrams per day. This article will explore the symptoms and consequences of zinc deficiency, plus arm you with a list of the top 12 foods with zinc, so you’ll never have to go without this important nutrient.

Symptoms of Zinc Deficiency and Those at Risk

If you are a vegetarian or vegan, you might be more prone to zinc deficiency due to a lack of meat in your diet. Likewise those with digestive diseases such as Crohn’s disease, celiac disease, or ulcerative colitis may develop a deficiency due to poor absorption rates. Those with certain cancers, alcohol addiction, or diabetes are also at a higher risk. Breastfeeding and pregnant women, the elderly, as well as children and teens run the risk of becoming zinc deficient more easily. What follows next is a list of symptoms, so you can better recognize the signs of zinc deficiency.

  • Slowed growth
  • Poor immune functioning
  • Appetite loss
  • Hair loss
  • Impaired wound healing
  • Diarrhea
  • Unexplained weight loss
  • Compromised night vision
  • White spots on nails
  • A funny-tasting sensation
  • Lethargy
  • Fine tremors (unintentional muscle movements)

A moderate deficiency can be fixed with dietary changes. A severe deficiency may require zinc supplements and advice from a medical professional on how to best restore zinc levels.

The Top 12 Foods with Zinc

If you’re looking for foods high in zinc, look no further than the following list of top 12 zinc-rich foods.

The top 12 foods with zinc.

1. Legumes

Legumes include lentils, beans, and chickpeas, and are some of the best foods around for those who don’t eat meat to gain plant sources of protein and zinc. In 100 grams of lentils for example, you can get 12% of the daily recommended intake of zinc (for a man or pregnant/nursing woman).

Animal sources of zinc are better absorbed due to the fact that legumes also contain phytates, which can inhibit the absorption of zinc and other minerals. Regardless, legumes are an excellent source of fiber and protein that can be easily included in stews, salads, and soups—an easy and beneficial addition.

Bioavailability can also be increased with sprouting, fermenting, and soaking plant sources of zinc, which is great news for those seeking foods with zinc for vegan diets.

2. Meat

Meat is a strong source of zinc, especially red meat. Lamb, pork, bison, and beef are foods with high zinc and iron content, plus creatine and B vitamins. For zinc, raw ground beef contains 4.8 milligrams of zinc, 43% of a man’s RDI.

Though not everyone will want to eat large amounts of red meat due to its association with heart disease, it can still nevertheless be included moderately in a balanced diet to gain the positives without risking much in negative effects.

3. Seeds

Squash seeds, flaxseeds, sesame seeds, hemp seeds, and pumpkin seeds: all of these seeds help increase your zinc intake. They can be easily added to other foods like yogurts and salads, or enjoyed on their own as snacks in trail mixes or granola bars.

Some seeds contain more zinc than others. Hemp seeds in particular have 31% of a man’s RDI in just 3 tablespoons (30 grams) of seeds. That being said, sesame, squash, and pumpkin seeds each have significant amounts of zinc, as well as fiber, vitamins, minerals, and healthy fats. Including more seeds in your diet can help to lower blood pressure and reduce cholesterol, so they’re a fantastic resource for your health.

4. Shellfish

Shellfish like oysters and shrimp are low-calorie, healthy sources of zinc. Just six medium oysters can provide 32 milligrams of zinc, 290% of a man’s recommended daily intake. This category includes Alaskan crab, clams, scallops, mussels, and lobster.

It’s recommended that you cook shellfish thoroughly to avoid food poisoning, and also that you use a wet heat method of cooking like steaming, boiling, poaching, or braising instead of dry heat methods like grilling, broiling, sautéing, roasting, or baking, as those tend to reduce the zinc levels in shellfish.

5. Eggs

Eggs have about 5% of a man’s RDI per large whole egg, and they also bring 5 grams of healthy fats, 6 grams of protein, and vitamins and minerals. One of the foods with high zinc and selenium content, eggs also have an assortment of B vitamins and choline, which is important for many of the steps in our metabolism, and a nutrient that most of us do not get enough of from our diets.

6. Nuts

Cashews, almonds, peanuts (yes, we know technically they’re legumes but we’re eating them like nuts!), pine nuts, and more: all of these nuts can boost your zinc intake, as well as provide healthy fats, fiber, and a dazzling array of other vitamins and nutrients like iron, calcium, vitamin E, and folate.

Nuts are foods with zinc and magnesium, and among the nuts, your best source of zinc are cashews, with about 14% of a man’s RDI amount in a 1-ounce serving. Convenient, hearth healthy, and excellent for reducing the risk factors of diabetes, nuts have also been associated with greater longevity.

7. Certain Vegetables

Though vegetables and plant foods tend to be poorer sources of zinc than animal products, it’s nevertheless possible to get zinc from certain vegetables. For those who don’t eat meat, both sweet and regular potatoes have about 1 gram of zinc per large spud, 9% of a man’s daily recommended. Green veggies like green beans and kale contribute a small portion of zinc as well, about 3% of the RDI per 100 grams. While they may not contain a lot of zinc, greens like kale do contain chart-topping portions of vitamin K and vitamin A, and a vegetable-rich diet is associated with risk reduction for conditions like heart disease and cancer.

8. Dairy Products

Dairy products like milk and cheese have high amounts of particularly bioavailable zinc, meaning it’s more easily absorbed by your body. Just 100 grams of cheddar cheese has around 28% of a man’s RDI of zinc, and 1 cup of full-fat milk has about 9%. With calcium for bone health, vitamin D, and protein, dairy products are good sources of zinc, especially for any lacto-vegetarians.

9. Certain Fruits

Zinc-rich fruits include avocados, blackberries, pomegranate, raspberries, guava, cantaloupe, apricots, peaches, kiwifruit, and blueberries. With healthy fats in avocados and the anti-inflammatory and antioxidant properties of berries, though they don’t have very much zinc content compared to animal sources, these fruits are nevertheless more food sources that can help keep your body plentiful with zinc.

10. Whole Grains

Wheat, rice, oats, and quinoa each contain some zinc, though like the legumes listed above, they also contain phytates that can bind with zinc and inhibit its absorption. Whole grains contain more phytates than refined grains do, but they are still better for your health overall, as they also contain nutrients like B vitamins, selenium, magnesium, iron, and valuable fiber. Eating whole grains is associated with a reduced risk of obesity, type 2 diabetes, and heart disease, and so very much worth including in your diet for the other health benefits they bring.

11. Dark Chocolate

Among the foods with zinc and copper, dark chocolate has pretty fair amounts of zinc, about 30% of a man’s daily recommended intake with 3.3 milligrams of zinc per 100 grams. The only issue, of course, is that 100 grams of dark chocolate means 600 calories worth of food, so though dark chocolate has valuable nutrient content, it’s still a food that is best eaten in moderation, and not thought of as a main source of zinc.

12. Fortified Breakfast Cereals

Fortified breakfast cereals are a good source of zinc because they’re designed to make up the difference in specific vitamins and nutrients we’re often lacking in our diets. Great for growing children and adults, certain breakfast cereals will not only provide you with the benefits of zinc, but also with calcium, dietary fiber, and a cavalcade of vitamins.

From A to Zinc

Good sources of zinc like meat, nuts, seafood, dairy, and legumes are great to have as staples in your diet. The foods containing only marginal amounts of this essential mineral are still important too, as they round out your diet in a balanced fashion. Now you know that foods containing zinc are as diverse as they come, from just about every building block on the food pyramid. With their help, you could get regular amounts of zinc every day, and hardly notice the effort!

Serrapeptase: The Science Behind the Supplement

Mostly used by health care professionals in Japan and Europe for reducing inflammation after trauma, surgery, or in other inflammatory circumstances, serrapeptase is also available as a dietary supplement for its various health benefits. Find out what serrapeptase is, how it was discovered, and which of its supposed benefits have the strongest evidence backing them.

Serrapeptase, also known as serratiopeptidase, serratia peptidase, or silk worm enzyme, is an isolated enzyme from bacteria found in silk worms. Mostly used by health care professionals in Japan and Europe for reducing inflammation after trauma, surgery, or in other inflammatory circumstances, it is also available as a dietary supplement for its various health benefits. This article will explore the science behind those health claims, discuss the potential side effects of serrapeptase, and help you decide whether this anti-inflammatory is right for you.

What Is Serrapeptase?

The serrapeptase enzyme is a proteolytic enzyme, which means it has the ability to break down proteins into their building blocks, amino acids. It’s an enzyme produced by the bacteria living in the silk worm’s digestive tract, and specifically it’s the enzyme that allows an emerging moth to dissolve and digest its own cocoon. If you’re the kind of person who finds bugs and worms to be skin-crawlingly gross, it might do you well to think less about where this enzyme comes from, and more about what it and other proteolytic enzymes like bromelain, chymotrypsin, and trypsin can do to benefit you.

Discovered throughout the 1950s, these enzymes were used in the United States to relieve the inflammation caused by ulcerative colitis, rheumatoid arthritis, and post-surgical swelling. By 1957, the Japanese were using serrapeptase in the same manner, and in the 1990s these different enzymes were compared and it was found that serrapeptase was the most successful at reducing inflammatory responses. Since then it has become more widely used in Europe and Japan for its anti-inflammatory benefits.

The Benefits of Serrapeptase

Though serrapeptase is relatively new to the medicinal scene, there have nevertheless been many studies done to document its effectiveness and safety. Here are some of the benefits that have been observed from the use of serrapeptase.

Serrapeptase supplements: the science and the speculation.

May Reduce Inflammation

This is the health benefit serrapeptase is best known for, reducing inflammation in instances like tooth removal or post-surgery recovery. It’s thought that serrapeptase works by decreasing inflammatory cells at the site of injury. The anti-inflammatory effects of serrapeptase were shown in a clinical trial on the surgical removal of wisdom teeth, and serrapeptase was found to be more effective at improving lockjaw than more powerful drugs like ibuprofen and corticosteroids.

Though corticosteroids improved facial swelling more effectively on the first day post-surgery, the differences on the second day were insignificant. While more research is still needed to define the best uses of serrapeptase going forward, the researchers in the study did note that serrapeptase had a better safety profile than the other drugs analyzed, which may make it particularly useful in cases of drug intolerance in patients, or those who have adverse side effects with stronger drugs.

May Prevent Infections

There is evidence that serrapeptase may decrease the risk of bacterial infection by acting as a “biofilm buster,” so-called because bacteria have the ability to join together and form a protective barrier or film around themselves. The biofilm shields them from antibiotics long enough that their rapid growth can take place and cause infection. Serrapeptase can inhibit the formation of biofilms, increasing the efficacy of antibiotics in cases like Staphylococcus aureus (Staph. aureus), or staph infection, one of the most common opportunistic dangers associated with hospital stays.

Both animal and test-tube studies have shown that serrapeptase combined with antibiotics was more effective than treating Staph. aureus with antibiotics alone, including those strains that have become drug-resistant. An example of a drug-resistant form of staph infection is MRSA (methicillin resistant Staph. aureus), an especially dangerous infection to those who are already hospitalized in immune-compromised states.

May Reduce Pain

Pain being a symptom of inflammation, serrapeptase has been known to reduce pain by inhibiting certain compounds. For example, in one double-blind study that examined the effects of serrapeptase in about 200 people with inflammatory conditions of the ear, nose, and throat, researchers found that those who took a serrapeptase supplement had significant reductions in mucus production and pain severity than did those who took a placebo.

Another study found that serrapeptase reduced pain significantly compared to a placebo in 24 participants following the removal of their wisdom teeth. More research is needed for scientists to be sure of serrapeptase’s effects, but these findings show promise for those hoping to avoid nonsteroidal anti-inflammatory drugs (NSAIDs) after medical procedures.

May Help Dissolve Blood Clots

It is thought that by acting to break down fibrin (a protein formed in blood clots) as well as damaged and dead tissue, the serrapeptase enzyme could help treat atherosclerosis. Atherosclerosis involves plaque buildup inside your arteries, which leads to a hardening and narrowing of the arteries and an increased danger from blood clots.

If serrapeptase is successful at dissolving plaque or blood clots, it could reduce a person’s risk of stroke or heart attack. However, not enough studies have been done showing a direct effect, and so while there is potential that serrapeptase has a role in treating blood clots, more research is warranted.

May Be an Aid Against Chronic Respiratory Disease

Chronic respiratory and chronic airway diseases affect the lungs and breathing apparatuses of the body. Serrapeptase’s potential to clear mucus and reduce inflammation in the the lungs could help improve breathing in those with asthma, chronic obstructive pulmonary disease (COPD), and pulmonary hypertension, which is a form of high blood pressure in the vessels of your lungs.

These chronic conditions are ongoing and incurable, and yet managing the symptoms effectively (as with increased mucus clearance and better dilation of air passages) can greatly improve a person’s quality of life. One month-long study of 29 participants with chronic bronchitis involved a test group that was given 30 milligrams of serrapeptase per day, which resulted in less mucus production than the control group, better lung-clearing ability, and greater ease of breathing.

May Treat Endometriosis

Due to the potential serrapeptase has for targeting dead tissue and scar tissue throughout the body, some believe there is potential in using serrapeptase for endometriosis treatment. Endometriosis occurs when endometrial cells grow outside the uterus, in the tissues surrounding the pelvic area, causing pain and often issues with fertility.

Likewise with conception issues arising due to ovarian or uterine cysts, serrapeptase for fertility is another natural therapy that currently has more anecdotal evidence than scientific research done on it, though that does not mean the research won’t be done, nor that it wouldn’t be a safe supplement to try in consultation with a qualified health care professional.

May Help Relieve Alzheimer’s Disease

One study on rat models revealed that the proteolytic enzymes nattokinase and serrapeptase may have a therapeutic application in the treatment of Alzheimer’s disease, modulating the different factors that characterize the disease. Oral application of these enzymes provided a decrease in transforming growth factor, acetylcholinesterase activity, and interleukin-6, all of which are found in high levels among patients with Alzheimer’s disease. While more research still needs to be done, Alzheimer’s is a medical condition that needs any relief options available.

Potential Serrapeptase Side Effects

Because it’s such a new commodity, people are rightly concerned that there could be potential serrapeptase dangers. There are not many published studies touching on potential adverse reactions to taking serrapeptase, however some studies have reported the following side effects.

As there is a lack of data on the long-term safety and tolerability of this enzyme, should any side effect occur after you take it, you should stop immediately and seek medical advice. What works for some may not work for all, and so your judgement is paramount when it comes to whether you’re getting the benefits you want.

How to Take Serrapeptase

It’s advised against taking serrapeptase with any sort of blood thinner, or other dietary supplements like turmeric, garlic, or fish oil which could increase a risk of bruising or bleeding. For serrapeptase dosage, it’s recommended to take between 10-60 milligrams per day (the range used within the various studies) on an empty stomach, and to avoid eating for at least 30 minutes afterwards.

When purchasing the supplement, choose a product in an enteric-coated capsule to prevent your stomach acid from neutralizing the enzyme before it reaches your intestine. Without a strong enough capsule, the enzymatic activity could be deactivated before it has a chance to work.

How long does it take serrapeptase to work after you take it? For pain and swelling it can have immediate effects post-surgery, but for more gradual or ongoing treatments, the effects might be felt over a period of weeks. It truly depends on your condition, your health, and how you’re using the supplement.

The Secrets of Serrapeptase

Our understanding of serrapeptase is far from comprehensive at this moment. There is one study linking it to treatment of carpal tunnel syndrome and anecdotal evidence suggesting serrapeptase for weight loss (albeit temporary). There are far more clinical studies on the use of serrapeptase for reducing inflammation, fighting infections, and preventing blood clots, but researchers are still exploring its uses. Should you be interested in seeing what serrapeptase supplementation can do for you, we only ask that you do so wisely, and with a willingness to consult a medical professional about any results you find, be they bad or good.

Unexplained Weight Loss: What Could It Mean?

Unexplained weight loss could be due to dangerous underlying causes, from infections, to disorders, to conditions as serious as congestive heart failure and cancer. 

Under normal circumstances, people have to work hard to control their weight, whether they’re trying to slim down or bulk up. Sudden, noticeable, weight loss is often a symptom of an underlying health concern, and unexplained weight loss is even more worrying, as it could be an indication that something is wrong with your body, but is currently undiagnosed. This article will detail some of the usual suspects behind unintentional weight loss, so you can better understand how important it is to identify the underlying cause.

How Much Weight Loss Is Concerning?

It’s common to fluctuate between 1-3 pounds per day according to your scale; those are just the vagaries of water weight. However, a loss of 10 pounds or more (or 5% of your body weight) over a 6-12 month period with no known reason warrants concern. If you’ve changed your habits, changed your diet, or undergone a change in life that could explain the reduction in weight, then it may not be that unusual, but you may benefit from asking yourself some questions.

  • Did you start a new job?
  • Did you move to a new area?
  • Are you under some known form of stress (whether happy or unfortunate—i.e. planning a wedding or caring for a sick loved one).
  • Has there been a change in your relationship status?

It’s important to know, because while this sort of steady weight loss would be welcome if you’d changed your diet with the intention to lose weight (by transitioning from processed to whole foods for example), if no alterations to your diet or lifestyle have been made and your weight has still gone down this dramatically, there may be some serious underlying reasons.

Losing Weight Without Trying: Am I Sick?

Unexplained weight loss could be the first sign of sickness, yes. You should contact a doctor or health care professional right away to seek evaluation, as the causes for unexplained weight loss can be quite serious, from infections, to thyroid issues, to the terrifying prospect of cancer (but please don’t go to the extreme scenario…just go to a doctor!).

The good news is that doctors quickly find the cause of abnormal weight loss in over 75% of cases. In fact, even if you think you know the cause, something like general stress and anxiety could be masking a physical health problem, and you should make an appointment to be sure this weight loss isn’t caused by a combination of issues or that it isn’t taxing your health in other ways.

If the first examination isn’t thorough enough, seek a second opinion to rule out other causes. Blood tests, a urinalysis, a thyroid panel, liver and kidney function tests, a blood sugar test, or imaging studies may need to be done to make sure there are no red flags in your health profile.

Your doctor may ask:

  • Have you made any changes in your exercise or diet recently?
  • Has this sort of weight loss ever happened to you before?
  • Do you have any dental problems or mouth sores that could impede your ability to eat normally?
  • Is there a history of any particular illness that runs in your family?
  • Do you have any other concerning symptoms (palpitations, excessive thirst, sensitivity to heat or cold, a persistent cough, shortness of breath)?

Consider your overall health as you prepare for your appointment, so you can make sure your doctor is informed of any symptom that might be relevant to your condition.

Why Diagnosis Is Important

There are many medical conditions that might lead to unintentional weight loss. The American Cancer Society points out that 50% of all cancer patients have a form of cancer cachexia, a wasting syndrome that involves unintentional weight loss and brings on the death of about 20% of cancer patients.

It is the same with cardiac events. One study explicitly states, “Unintentional weight loss was an independent predictor of poor outcomes.” Unintentional weight loss brings about higher morbidity, mortality, and bodes ill for anyone already battling a disease. That is why identifying and treating unexplained weight loss is so important, especially in older adults (above age 65), who are all the more at risk of serious consequences from any sudden change in health.

Possible Causes of Unexplained Weight Loss

We’ll now run down some of the common causes of unintentional or abnormal weight loss.

Unexplained weight loss: possible underlying causes.

Endocrine Conditions

Endocrine conditions include hyperthyroidism (an overactive thyroid), hypothyroidism (an underactive thyroid), diabetes, and Addison’s disease (wherein the adrenal glands don’t produce enough hormones). The thyroid gland is located in your neck, is somewhat butterfly-shaped, and controls your metabolism. An issue with the thyroid gland could be accompanied by heart palpitations, and if type 2 diabetes is at play, you’re likely to experience increased thirst and excessive urination as your body tries to expel all the glucose it can’t absorb.

Infections

Infections include anything from parasites, bacterial infections, and viruses (which HIV/AIDS patients are more susceptible to), along with conditions like endocarditis (an infection of the heart valves), or tuberculosis (an infection of the lungs). In these instances, your body is losing weight because it is using all of its resources to fight off an invasion.

Cancer

Weight loss can sometimes be one of the earliest symptoms of cancer, such as from lung cancer, ovarian cancer, colon cancer, pancreatic cancer, or blood-related cancers like lymphomas and leukemias. About 40% of cancer patients report having experienced weight loss around the time of their diagnosis, and studies have shown that unintentional weight loss is the second highest predictor for certain cancers. Weight loss often occurs as a result of cancer due to the body’s nourishing efforts being hijacked to support an abnormal tumor growth. Doctors will often check first for tumors in the bowels, colon, and esophagus, which can impede swallowing and quickly contribute to unintentional weight loss.

Intestinal Conditions

Conditions like celiac disease, peptic ulcer disease, Crohn’s disease, ulcerative colitis, and pancreatitis can lead to unexplained weight loss in those who have yet to be diagnosed.

Celiac disease is an autoimmune disorder wherein the small intestine is damaged by gluten intake, leading to GI symptoms like diarrhea and bloating. According to the Mayo Clinic, when the immune system sees gluten as a threat, it reacts, and that reaction means your body doesn’t have a chance to absorb its nutrients properly. Likewise, in an inflammatory bowel disease like Crohn’s, the body’s reaction leads to malabsorption and unexplained loss of weight.

Those with chronic pancreatitis lose weight due to the fact that their body cannot produce enough digestive enzymes to properly break down food (and this may come with nausea, particularly from eating fatty foods).

Heart Failure

Congestive heart failure may cause weight loss due to a lack of sufficient blood flow to the GI tract. In a 2014 study researchers observed that those who had the most dramatic unintentional weight loss were indeed those who had the lowest blood flow to their intestines. Inadequate blood flow makes it harder to absorb nutrients, and the nausea and fatigue associated with congestive heart failure could lead to a loss of appetite.

Eating Disorders

Eating disorders like bulimia and anorexia nervosa can cause dangerous weight loss, and while it might not be a completely unknown cause to the person suffering from the condition, it can be an indicator to a loved one or parent that something is wrong. Moreover, because of the nature of body dysmorphia, those coping with these eating disorders may not fully realize just how significant their weight loss is until it starts causing other health symptoms due to malnutrition.

Psychological Conditions

Depression and anxiety disorders often come with loss of appetite as a side effect, and can be an underlying cause of unexplained weight loss. It often goes unnoticed until the weight loss is significant enough, and will involve a different sort of diagnosis, as these are not conditions that can be found via imaging scan or blood test.

Drug Abuse

Be they extralegally obtained drugs or prescription medications, drug dependence can alter your body’s metabolic and digestive processes, and change your eating habits. Side effects from medications could lead to nausea, loss of appetite, or laxative effects that can contribute to unintentional weight loss as well.

Neurological Conditions

Unintentional weight loss is frequently seen in those with Parkinson’s disease and Alzheimer’s. This is possibly due to the increased energy expense of rigidity, tremors, or dyskinesia (involuntary movements) associated with Parkinson’s, or the reduced energy intake due to poor health, stress, or the side effects of medication.

Rheumatoid Arthritis

When the immune system causes inflammatory reactions in healthy tissues, as in those with rheumatoid arthritis, it can also lead to a loss of appetite or an inflammation of the gut that interrupts nutrient absorption.

Reproductive Issues

Unexplained weight loss during menopause is unnatural, as it’s more common that menopause cause weight gain in women experiencing the change. Unintentional weight loss surrounding menopause could indicate that the changes in hormones has caused or made you susceptible to some other condition (stress, diabetes).

Likewise, unexplained weight loss during pregnancy is the opposite of the normal course of order. In the first few months, a loss of appetite due to morning sickness could be the culprit behind unintentional weight loss, but excessive weight loss could be a sign of a thyroid dysfunction or hyperemesis, a pregnancy complication that entails vomiting, severe nausea, dehydration, and weight loss. Your obstetrician should be made aware of any such symptoms.

An Explanation Is Necessary

Unknown causes of weight loss include a lot of scary and potentially life-threatening concerns. It’s normal for your weight to fluctuate by a few pounds here or there throughout the course of the year, but if you cannot determine a cause for sudden, steady weight loss, it’s important to consult with a medical professional and investigate: in fact, it could save your life.

Autophagy and Fasting: What Does the Science Say?

Autophagy is the body’s recycling program, which can be triggered by intermittent fasting. Autophagy is key in removing the toxins associated with neurodegenerative diseases, reusing residual proteins for energy and repair, and prompting the regeneration of cells throughout our bodies.

This article will discuss what autophagy fasting is, how it works, and whether or not the science backs up this practice.

What Is Autophagy?

We’ll start with the definition of autophagy: “auto” meaning “self” and “phagy” meaning “eats” tells you that the literal translation of autophagy is “self-eating.” That sounds scarier than the reality—we’re not talking about some flesh-eating bacteria or even the more common sort of self-cannibalization that our bodies do to our muscles when in need of energy, catabolizing.

Autophagy is more like a recycling program, or cutting your hair to keep it healthy and free of split-ends. It’s the body’s process of clearing out damaged cells so that it can regenerate new and healthier cells in their place. It’s almost like the internal equivalent of the exfoliating we do outside to keep our skin healthy.

The Details of Autophagy

Autophagy is a highly regulated process that delivers cellular waste material to lysosomes to be degraded, recycled, and then used to generate molecules to fuel cellular metabolism. For the specifics: scientist and Nobel prize winner Christian de Duve coined the term autophagy in 1962, when researchers discovered an increased amount of lysosomes in rat liver cells after an infusion of glucagon. It was also discovered that autophagy is regulated in part by the kinase mammalian target of rapamycin (mTOR), which promotes or represses autophagy as needed.

Autophagy and fasting: your body's recycling program.

What Does Autophagy Do?

The normal process of autophagy impacts your body and your health in various ways.

Promotes Metabolic Efficiency

The dysregulation of autophagy may contribute to developing metabolic disorders like insulin resistance, obesity, diabetes mellitus, osteoporosis, and atherosclerosis. From the very cellular level, autophagy can be used to improve the efficiency of mitochondria. The mitochondria in cells are the energy-makers, and the process of autophagy feeds them proteins from damaged cells that would otherwise either go to waste, or clog up other processes in the body.

Assists Against Neurodegenerative Disorders

In cases of Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease, selective autophagy can help clean up the specific proteins that form in and around the brain’s neurons and result in neurodegenerative symptoms. While autophagy was previously thought of as a nonselective process of digestion, it’s now understood that autophagy receptors make this a selective process, involving a cellular form of quality control.

Fights Infectious Disease

One of the central functions of autophagy is to control infections. It removes the toxins that create infections and helps your immune system adapt its response to infection. Viruses as well as intracellular microorganisms and bacteria can be removed via autophagy.

Improves Muscle Performance

The oxidative stress placed on our cells during exercise can trigger instances of autophagy to help remove some of the damaged cellular debris and support our energy needs. Autophagy is necessary for exercise-induced muscle adaptation and the improvement of physical performance.

Prevents Cancer Growth

This is a double-edged sword, because while autophagy can clean up the damaged DNA and chronic inflammatory aspects of cancer development, some forms of cancer will attempt to usurp the process and use it to a detrimental advantage. Regulating the autophagy pathway is important for inhibiting cancer growth.

What Is Autophagy from Fasting?

Autophagy via fasting occurs when you take the reins of autophagy by carefully controlling your dietary intake. This is usually done in an attempt to trigger safe yet fast weight loss. Here are two types of dieting that can bring about targeted autophagy.

Autophagy via Intermittent Fasting

Stressing your cells is a quick way to turn on the autophagy process in your body, but you don’t want to overly stress your body for too long lest the cure be worse than the cold. Intermittent fasting can create a useful nutrient deprivation in your cells, just as exercising will create a certain amount of oxidative stress to purposefully trigger your repair mechanisms into building muscle.

Intermittent fasting is not so much a diet as a pattern of eating, with daily short-term fasting of 16 hours, or longer fasts of 24 hours twice a week. How long until autophagy from fasting begins? It begins whenever your liver glycogen depletes, which occurs between 12-16 hours into a fast. This isn’t a deprivation so much as a return to the eating pattern humans evolved to survive under when we didn’t have supermarkets open 24/7. Intermittent fasting in that sense is more natural than eating three square meals a day, and can lead to long-term, sustainable weight loss, as well as better overall health when practiced…well, intermittently.

Autophagy via Ketosis

The ketogenic diet (or keto diet) is another way to get the benefits of fasting without actually fasting. This high-fat, low-carb diet breaks down to about 75% of your daily calories from fat, 20% from protein, and 5% from carbohydrates.

By putting a caloric restriction on carbs, you end up shifting your body’s go-to source of energy from quick glucose to fat. That fat burning starts first with the fat you eat, and then quickly turns to burning the fat stores already on your body for a reliable energy source. This produces ketone bodies that bring protective effects, and research suggests that ketosis can also bring about periods of autophagy, which has its own health benefits for the body.

Autophagy via Exercise

Exercise is a non-diet-related way of inducing autophagy. An animal study suggests that physical exercise may bring about autophagy in specific organs that are involved in metabolic regulation, namely the pancreas, liver, adipose tissue, and muscles.

Adding intermittent fasting and regular exercise to your lifestyle is an excellent way to stimulate autophagy in your body. To make sure you have the ability to build muscle while fasting or utilizing calorie restrictions, you may want to supplement with a full host of the amino acids necessary for protein synthesis. That way the required ingredients for new muscle are never out of balance.

The Potential Benefits of Autophagy

Autophagy is the body’s way of replacing old cells with new and younger ones, a regeneration effect that can help optimize our lifespans. As with any process in the body, autophagy declines as we age—waste accumulates and the regeneration rate decreases. This invariably leads to many symptoms of aging, which is why targeted autophagy fasting is so appealing.

Autophagy and Anti-Aging Potential

The benefits of autophagy are still being explored by scientists for its anti-aging potential, from the cellular level of the brain to the surface level of the skin. Those looking to employ autophagy via fasting to the loose skin left over after dramatic weight loss can find hope in studies suggesting that the slowing of natural autophagy is associated with a deterioration of dermal integrity, and that the fibroblasts that produce collagen (which keeps our skin youthful and pliable) suffer when autophagy decreases as we age. It stands to reason that if our collagen-producing fibroblasts get clogged due to a lack of autophagy, a targeted increase in autophagy frequency can free them up again, thus preventing and counteracting the aging of our skin.

Autophagy and Anti-Cancer Potential

The buildup of cellular waste affects our bodies from surface to core, as discussed previously with neurodegenerative diseases like Parkinson’s. Fasting and autophagy applied to cancer treatment have been shown to inhibit tumor growth. Autophagy fasting is still being fully explored by researchers hoping to prevent cancers from forming via the clean-up efforts of autophagy.

Some studies indicate that cancerous cells can be detected and destroyed through autophagy, before they can proliferate and start using the body’s processes against itself. Targeted use of autophagy, and keeping that process from being hijacked by cancers, may lead to new therapies for cancer treatment.

Fasting for Autophagy

Autophagy is our body’s recycling program, beneficial in removing the toxins associated with neurodegenerative diseases, reusing residual proteins for energy and repair, and prompting the regeneration of new and healthy cells throughout our bodies. On a cellular level, it’s like a regeneration episode of Doctor Who, but instead of science fiction, this process is science fact, and you have the ability to use it to your health’s advantage via targeted fasting.

Muscle Atrophy: Causes, Treatment and Prevention

Learn about what causes muscle wasting or muscle atrophy, and how best to prevent and treat this condition, including through the use of physical therapy, medical intervention, and staying active. 

Muscle atrophy is essentially muscle wasting: it’s what happens when your muscles waste away, frequently as a result of a lack of physical activity. This article will explore the causes and symptoms of muscle atrophy, as well as preventative steps people can take if they’re immobile or bedridden due to illness. Loss of muscle mass or muscle strength can be particularly devastating for those who are already in positions of compromised health, and so in an effort to help you maintain your quality of life, we’ve compiled the relevant information here.

Muscle Atrophy: Definition

Atrophy of the muscles occurs when a person is inactive for so long that their skeletal muscles (these are the muscles attached to your bones which literally make your skeleton move) begin to break down, and the muscle protein is cannibalized by the body. This can happen in small instances or large, catastrophic instances.

Muscle atrophy of the hand or forearm may occur if you spend weeks in a cast to heal a broken arm, which is why people in casts are given exercises to do while they’re immobilized to prevent protein degradation in their muscles and muscle wasting. Muscle atrophy of the legs or muscle atrophy of the thighs can happen on a much larger scale to those who become wheelchair-bound, either temporarily or due to becoming permanently paraplegic. In even more extreme cases, those who have been held as prisoners of war may have full-body muscle wasting due to confinement and malnutrition for significantly long periods, sometimes years.

Muscle atrophy is a decrease in muscle mass, either partial or complete, which is most commonly suffered when a person becomes disabled or their movements severely restricted. This makes it difficult or impossible to move the part of the body where the muscle has atrophied, and medical advice should be sought for solutions.

Muscle atrophy: causes, treatment, and prevention.

Muscle Atrophy: Causes

Significant decreases in activity levels can lead to muscle atrophy, and there are many situations where that can occur, causing what’s known as disuse atrophy. There are also instances of muscle atrophy due to medical conditions that inhibit the use of a body part, and even rarer causes like the muscle atrophy experienced by astronauts after relatively short periods (a few days) of weightlessness. Muscle atrophy in situations of being bedbound or ceasing intense physical training can come on in as little as 2 weeks. Some of the other causes of muscle atrophy are as follows.

  • Lack of physical activity
  • Advanced aging
  • Malnutrition
  • Stroke
  • Alcohol-associated myopathy
  • Burns
  • Temporary disabling injuries (broken bones, torn rotator cuff)
  • Permanently disabling injuries (severed spinal cord, peripheral nerve damage)
  • Prolonged corticosteroid therapy

Some of the diseases and medical conditions that can disrupt or restrict movement, thus leading to muscle atrophy, include:

  • Spinal muscular atrophy: A hereditary wasting disease of the limbs.
  • Osteoarthritis: Degeneration of bones and joint cartilage that leads to decreased movement.
  • Polymyositis: An inflammatory disease of the muscles.
  • Amyotrophic lateral sclerosis (ALS or Lou Gehrig’s disease): Compromises the nerve cells of the spinal cord.
  • Muscular dystrophy: A hereditary disease that causes muscle weakness.
  • Multiple sclerosis (MS): An autoimmune disease that destroys the protective sheathing of brain and spinal nerves.
  • Rheumatoid arthritis (RA): A chronic inflammatory disease of the joints.
  • Dermatomyositis: Inflammation of the skin and underlying muscle tissue.
  • Polio: A virus afflicting muscle tissue, which can lead to paralysis.
  • Cancer cachexia: The weight loss, lack of energy, and loss of appetite in someone undergoing cancer treatment.
  • Guillain-Barré syndrome: An autoimmune disease and form of polyneuritis, which leads to paralysis of the limbs.
  • Neuropathy: Nerve damage that results in loss of sensation or functioning.

Muscle Atrophy: Symptoms

Regardless of the cause, these are the symptoms that may alert you to possible muscle atrophy, after which a trusted medical professional should be sought for advice.

  • One of your limbs (arms, legs) appears markedly smaller than the other one.
  • You’ve spent a long time physically inactive (bedridden, hospitalized).
  • You’re experiencing noticeable weakness in one limb.

Not to be flippant about the subject, but there is some truth to the phrase “use it or lose it” when it comes to muscle. If you cannot move your muscles with regular physical activity, you will start to lose them.

Muscle atrophy pain may or may not be a symptom, as that depends on the cause of the atrophy. Many people will begin to lose muscle before they are aware it’s happening, and will have to rely on visual muscle size to realize they need medical attention.

Muscle Atrophy: Diagnosis

Once you’ve gotten in contact with a medical professional, the diagnosis may involve your full medical history, a review of any previous injuries, as well as an evaluation of your symptoms. Diagnosing the atrophy may also involve diagnosing the underlying medical condition, which may require blood tests, X-rays, MRIs, CTs, a nerve conduction study, or a muscle and/or nerve biopsy to find out what could be causing muscle atrophy if it’s not readily apparently (as it would be if you’d suddenly become bedbound).

Can Muscle Atrophy Be Reversed?

Depending on the cause, yes. There are some cases where a proper diet, exercise, and physical therapy can not only reverse muscle atrophy, but also prevent it from recurring. However, this will not be the case in some disease-related forms of atrophy, and it is important that you consult your doctor on what your expectations for muscle atrophy recovery should be in restimulating protein synthesis and rebuilding your muscles.

Muscle Atrophy: Treatment

Again, this will depend on the diagnosis of the cause, and also the severity of your muscle loss, but the treatments for reversible muscle atrophy may be as follows.

  • Physical therapy
  • Exercise
  • Ultrasound therapy
  • Dietary changes
  • Surgery
  • Electrical stimulation

If a lack of movement caused this condition, regaining movement will go a long way towards fixing it, and moderate exercise like walking, along with physical therapy, may be a way to regain muscle strength without needing surgery to fix skin, tendons, or ligaments too tight to begin moving again (as in cases of contracture deformity that could be caused by malnutrition or burn injury scar tissue).

Muscle Atrophy: Prevention

There are ways to prevent muscle atrophy before it happens, and ways to guard against it if you were fortunate enough to recover your musculature after one instance of muscle loss. If preventing muscle atrophy is in your control (and, of course, sometimes it will not be), here are a few ways to maintain muscle strength in adverse circumstances.

Stay Active

If you’re in recovery from a severe illness or have just come home from the hospital after a debilitating accident, it’s not as if you’ll take up jogging right away. However, movements as small as walking to your mailbox each day, or around the block, or up and down a single flight of stairs, can truly make the difference in the long run when it comes to maintaining your mobility.

Stay Nourished

Depending on your condition, this may be difficult, but when your body lacks the proper nutrition to stay running, it will start to catabolize your muscles for its needs, which is a form of self-cannibalization or destructive metabolism that literally eats away at your muscles. Make sure you’re getting proper protein, if not from whole foods, then in the forms of protein shakes or supplements, as every little bit may help.

In fact, supplementing with amino acids has been proven to help accelerate muscle recovery in times of sickness and illness and can help boost your muscle-building gains. To learn more about amino acid therapy for muscle atrophy, give this informative article, written by one of the world’s foremost amino acid researchers, a read.

Seek Physical Therapy

Physical therapy is particularly valuable for those with severe injury recovery (such as a car crash survivor) or a neurological condition, as therapists provide professional guidance on what, and how, and how often to stretch your body to build strength.

Try Passive Movement

Another way physical therapy can help you even before you have the strength to help yourself is with passive movement. Passive movement requires the therapist to gently move your legs and arms for you. This is how you can begin to recover from a very deep muscle deficit and build up strength and muscle again.

Preventative Measures

Not only will the above advice help prevent muscle atrophy, but it can also help discourage bedsores in those who are bedridden due to illness, and reduce the chances of developing dangerous blood clots in the limbs. Likewise, these movements may prevent muscle stiffness, retraction, and nerve damage. Consult a medical professional or licensed physical therapist for more advice.

Eliminate Atrophy

If you are in danger of muscle atrophy, take steps to make sure your protein intake and nutrients are sufficient, including the use of a supplement if necessary, like Amino Co.’s essential amino acid supplement, which contains all of the essential aminos required to build new muscle cells and structures. Also, make sure that you stay active, no matter in how small a way, to preserve your muscle function and prevent your muscles from falling into complete disuse. You cannot always control your body’s condition, but if the type of atrophy you fear is the type that’s preventable, it’s well worth the effort to maintain the quality of life and movement you’ve come to expect.

Acidic and Basic Amino Acids Explained

Discover the chemical differences between acidic and basic amino acids. Learn about the structure and nature of amino acids, the difference between acidic vs. basic substances, the pH scale used to measure them, and why these differences matter.

This article will quickly inform you of the difference between acidic and basic amino acids. We’ll provide the definitions and explanations you seek, including what are amino acids, what makes some of them acidic and some of them basic, and why that matters when it comes to the chemistry of the human body.

Amino Acids: Essential vs. Nonessential

Amino acids are the buildings blocks of protein in your body. In short, when it comes to protein synthesis and literally building new muscle, you cannot do it without your amino acids.

Nonessential Amino Acids

Your nonessential amino acids are the amino acids your body can create on its own as a byproduct of normal functioning. There are 11 of these amino acids, and they include the following:

  • Alanine (ala)
  • Arginine (arg)
  • Asparagine (asn)
  • Aspartic acid (asp)
  • Cysteine (cys)
  • Glutamic acid (glu)
  • Glutamine (gln)
  • Glycine (gly)
  • Proline (pro)
  • Serine (ser)
  • Tyrosine (tyr)

Essential Amino Acids

Your essential amino acids are the ones you need but cannot produce yourself, and so must be gained either from your diet or via supplementation. These amino acids include the following:

  • Histidine (his)
  • Isoleucine (ile)
  • Leucine (leu)
  • Lysine (lys)
  • Methionine (met)
  • Phenylalanine (phe)
  • Threonine (thr)
  • Tryptophan (typ)
  • Valine (val)

Now that you know the amino acids we’ll be talking about, let’s move on to an illustrative example of what an amino acid’s structure looks like.

Amino Acid Structure

To understand what differentiates amino acids, you’ll have to understand their structure and what they have in common. Each amino acid is made of a central alpha carbon atom (Cα), and attached to that central atom are three molecular structures, also known as functional groups: one is a carboxyl group (-COOH), the second is an amino group (-NH2), and the third is a single hydrogen atom (H). This is the same structure of all amino acids, until the last piece of the puzzle joins the rest: the R group side chain. The R group you can think of as the Radical group, as it is different and unique on each and every amino acid, of which there are 20 main ones in the human body.

Picture it, if you will, as a group of lava lamps. Each one is made up of a light bulb in the center, a power cord, a stand, and a cap. With a long row of 20 identical lava lamps, imagine that the only thing that would make any of them unique is the color combination inside its radical glass lava vessel. Maybe one vessel has blue water and green lava, while another one has purple water with yellow lava, while yet another has blue water combined with yellow lava. With 20 different color combinations, you have enough to represent all 20 amino acids. The light bulb in the center? That is your central alpha carbon. The power cord? The carboxyl group. The supporting stand? Your amino group. And the little decorative cap on top? Your single hydrogen atom.

We illustrate it this way because it’s that glass lava vessel that not only determines what kind of amino acid you have (i.e. what color your lava lamp is), but these side chains also determine whether or not an amino acid is basic or acidic. With that structure explained, let us next generally cover acid vs. base when it comes to a chemistry standpoint.

Acid vs. Base: The Basics About Acids

In chemistry, we’re talking about molecules (which are themselves made up of atoms). A base molecule or compound is the opposite of an acid. Acids are the compounds that donate a hydrogen ion (H+) to a base, while a base compound is one that can remove a proton (H+ is a proton) from an acid. A strong base molecule can deprotonate, or take the proton, of a weaker acid such as water.

Differences between acidic and basic amino acids.

Water, Acids, and Alkalis

Hydrogen molecules are why bases and acids are often measured in pH levels (pH stands for “potential of hydrogen”) as related to pure water. The pH scale goes from 0-14. The pH of pure water is 7, precisely in the middle.

When an acid is dissolved in water, it becomes a solution with higher hydrogen ion activity than water, making it more acidic, with a pH value less than 7. When a base dissolves in water, it creates a solution with lower hydrogen activity than water, giving a pH value greater than 7. Bases that dissolve in water are called alkalis. To summarize:

  • Pure water
    • pH level: 7
    • Pure water can be swallowed by humans, is neither corrosive nor caustic, and will not burn human skin.
  • Acids
    • pH level: less than 7 (<7)
    • Named from the Latin acidus or acere, meaning sour.
    • Acids are corrosive.
    • Acids lose their acidity when combined with alkalis.
    • Examples are: citric acid (lemon juice), acetic acid (vinegar), stomach acid, and battery acid.
  • Bases
    • pH level: greater than (>7)
    • Bases that can dissolve in water are also known as alkalis, or alkaline substances.
    • Alkalis are caustic.
    • When highly concentrated, a corrosive substance will cause a chemical burn.
    • Examples are: sea water, baking soda, ammonia, garden lime, and strong lye.

To recap: the further you get from pure water on the pH scale, the more corrosive or caustic a substance becomes, and thus the more harmful to human skin (for example). On the low end of acids, you can drink orange juice, and on the low end of bases, you can swim in sea water. On the high end of acids, you have battery acid, and on the high end of bases, you have bleach, drain cleaner, and lye, which you may remember from the 1999 movie Fight Club. It occurred when Brad Pitt’s character mixed human saliva with lye on Edward Norton’s character’s skin and stated, “This is a chemical burn. […] You can use water and make it worse, or use vinegar to neutralize the burn.” Vinegar is a 2 on the pH scale, an acid that can indeed neutralize a strong base like lye (a 13 on the pH scale).

Acidic and Basic Amino Acids

Of our amino acids, which are acidic, which are base, and why does it matter? First we’ll state which is which, while quickly pointing out that the acidity of amino acids is measured with a pKa number, obtained by applying a logarithm; simply put, pKa measures acid strength, while pH measures the hydrogen content of a solution.

As a further example, for acids that means the smaller the pKa number, the more acidic the substance, and thus the lower the pH value.

Acidic Amino Acids

The two acidic amino acids are:

  • Aspartate (aspartic acid)
  • Glutamate (glutamic acid)

Acidic amino acids are those with acidic side chains, specifically containing carboxylic acid groups with pKa measurements low enough to lose protons and become negatively charged. Acidic amino acids are also by their nature hydrophilic amino acids (meaning they like water, as opposed to hydrophobic amino acids), and polar amino acids (meaning they are positively charged, as opposed to nonpolar amino acids).

Basic Amino Acids

The three basic amino acids are:

  • Arginine
  • Histidine
  • Lysine

These basic amino acids are so classified because they have basic side chains containing nitrogen, which resemble ammonia (a base). The pKa values of basic amino acids are high enough to bind protons and give them a positive charge. By nature, basic amino acids are also polar amino acids, and are also hydrophilic, just like the acidic ones.

A for Acid, B for Base, C for Conclusion

In conclusion and to summarize: the difference between acidic and basic amino acids is the same as between any acid and base in chemistry and chemical substances. Their similarities still include being polar amino acids, as well as hydrophilic amino acids, and, of course, the biggest thing they have in common is that they’re all still amino acids, with the same basic structure.

Though some are essential and some nonessential, the reason amino acids matter, and the reason that all these tiny permutations matter, is because without each of them working together, our health and well-being would fail. We at Amino Co. have developed amino acid supplements specifically because we understand their vital importance to human life. The chemistry behind each person’s daily concert of amino acids is the science that drives our passion.