Essential amino acids protect against sarcopenia
Essential amino acids protect against sarcopenia

Amino Acid Supplementation Increases Lean Body Mass, Basal Muscle Protein Synthesis, and Insulin-Like Growth Factor-I Expression in Older Women


Insufficient protein intake plays a significant role in age-related muscle loss, known as sarcopenia. Studies show that elderly individuals get far below the recommended daily dietary protein intake. Nutritional supplements designed to meet protein needs often adversely affect voluntary food consumption. Supplementing with free-form essential amino acids, however, is a lower calorie, less satiating way to provide protein so that appetite and food consumption aren’t impacted. 

Previous research has shown that 6.7-15 grams of essential amino acids (EAAs) is the ideal dose to maximally stimulate muscle protein synthesis in older adults and potentially protect against sarcopenia. The long-term effects, however, remain unvalidated. The current study aimed to assess the long-term benefits of an optimal daily dose of essential amino acids. 

Trial Length

3 months

Number of Subjects




Age Range

66 - 70

The Goal

Researchers tested the effects of daily essential amino acid (EAA) supplementation on older women over 3 months to see if the short-term anabolic (muscle-building) gains could be sustained over the long term. They examined postabsorptive muscle protein fractional synthesis rate (FSR), lean body mass (LBM), one-repetition maximum muscle strength, and androgen receptor and IGF-I muscle protein expression.

The Results

Participants received either two doses of 7.5 grams of essential amino acids per day or a placebo every day for 3 months. 

Those in the EAA group had increases in muscle protein fractional synthesis rate (FSR) at 0 months and 3 months, while those in the control group only showed an increase in FSR when given 7.5 grams at the start of the study (0 months). Graph showing basal-mixed muscle FSR. EAAs were significantly more effective.Likewise, basal IGF-I protein increased in the EAA group after 3 months, as shown in Figure 2 below.Basal IGF-I protein increased in the EAA group after 3 months


Researchers concluded that 7.5 grams of essential amino acids ingested twice a day over the long term can improve lean body mass and muscle protein synthesis in older adults without any decrease in the anabolic response to EAAs. Targeted EAA supplementation may be able to counter the deleterious effects of sarcopenia. 

Resistance exercise and muscle strength

The present study showed that EAA supplementation had no effect on one-repetition maximum muscle strength, which was no surprise, as participants were sedentary and did not increase their physical activity over the 3 months. Researchers hypothesize that implementing an exercise program in conjunction with 15 grams of EAAs ingested daily could lead to strength gains in addition to improvements to lean muscle mass.  

The Why?

By 2030, almost 202 million people will be over 65 and battling the debilitating effects of sarcopenia. But sarcopenia is an age-related condition that can be treated. Along with resistance training, supplementing daily with 15 grams of essential amino acids can help stimulate muscle protein synthesis and increase lean body mass, thereby improving quality of life and decreasing the risk of morbidity and mortality associated with sarcopenia. 


Dillon EL, Sheffield-Moore M, Paddon-Jones D, et al. Amino acid supplementation increases lean body mass, basal muscle protein synthesis, and insulin-like growth factor-I expression in older women. J Clin Endocrinol Metab. 2009;94(5):1630-1637. doi:10.1210/jc.2008-1564