Diet enrichment with a specific essential free amino acid mixture improves healing of undressed wounds in aged rats
Over 6.5 million Americans are battling a chronic skin wound, a common health condition in the elderly population. Conventional wound care products fail to provide enough nutrients to skin cells in order to fuel tissue regeneration and speed healing. Researchers were interested in the potential of essential amino acids to accelerate wound healing when taken orally and without topical medication.
Number of Subjects
36 Sprague-Dawley rats
Based on previous studies, researchers suspected that oral supplementation with essential amino acids would speed wound healing without the use of topical medication. They compared wound closure dynamics and relevant signaling molecules in elderly rats supplemented with essential amino acids and control rats fed a standard laboratory diet.
Findings showed that rats on the essential amino acid diet experienced faster wound healing, as well as reduced inflammation and increased collagen synthesis.
Researchers concluded that nutritional intervention with essential amino acids can help accelerate wound repair by reducing inflammation and increasing collagen synthesis, and recommend future research into the therapeutic benefits of essential amino acids on chronic wounds.
As rates of diabetes and obesity continue to climb, geriatric medicine is focusing its efforts on developing strategies to speed wound healing. To meet skin cells’ increased demand for nutrients, researchers are investigating nutritional therapies. Essential amino acids hold promise as an effective nutritional intervention for wound care.
Corsetti G, Romano C, Pasini E, Marzetti E, Calvani R, Piccca A, Flati V, Dioguardi FS. Diet enrichment with a specific essential free amino acid mixture improves healing of undressed wounds in aged rats. Exp Gerontol 2017; 96:138-145. Doi 10:1016/].exger.2017.06.020.Epub 2017 Jun 29. PMID28669821