Metabolic Effects of Orally Administered Amino Acid Mixture in Elderly Subjects with Poorly Controlled Type 2 Diabetes Mellitus
Amino acids play an important role in glucose metabolism. Normal and high levels of amino acids in skeletal muscle tissue help to regulate the rate of glucose uptake, storage, and utilization.
Increased muscle protein breakdown and declines in muscle mass due to aging can impair glucose metabolism by contributing to high blood sugar levels and lowering insulin sensitivity in people with type 2 diabetes.
Increasing amino acid levels in skeletal muscle tissues may, therefore, be a potential strategy for controlling glucose metabolism and insulin sensitivity in older patients with poorly managed type 2 diabetes.
Number of Subjects
65 - 83
The aim of the present study was to determine if oral supplementation with an amino acid mixture (OAAM) made up of essential amino acids could enhance blood sugar control and insulin sensitivity in elderly individuals with poorly regulated type 2 diabetes.
Findings indicate that supplementation with an essential amino acid mixture reduces fasting and postprandial blood sugar levels as well as HbA1c levels within 8 weeks of treatment.
Researchers theorize that in addition to boosting muscle protein synthesis and glucose storage, amino acid supplementation helps to increase the uptake of glucose, thereby decreasing blood sugar levels.
Supplementing with an essential amino acid mixture improved glucose metabolism and insulin sensitivity in older type 2 diabetes patients, suggesting that essential amino acids may prove a beneficial nutritional strategy for the management of diabetes.
When poorly controlled, type 2 diabetes leads to spikes in glucose levels and reductions in insulin sensitivity. This study shows that supplementation with essential amino acids can help improve glucose metabolism and insulin sensitivity by increasing muscle protein synthesis without side effects.
Solerte SB, Gazzaruso C, Schifino N, et al. Metabolic effects of orally administered amino acid mixture in elderly subjects with poorly controlled type 2 diabetes mellitus. Am J Cardiol. 2004;93(8A):23A-29A. doi:10.1016/j.amjcard.2003.11.006